{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:58:55Z","timestamp":1756461535812,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012353","name":"Deutschen Konsortium f\u00fcr Translationale Krebsforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To demonstrate the feasibility of 3D echo\u2010planar spectroscopic imaging (EPSI) technique with rapid volumetric radial k\u2010space sampling for hyperpolarized (HP) <jats:sup>13<\/jats:sup>C magnetic resonance spectroscopic imaging (MRSI) in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A radial EPSI (rEPSI) was implemented on a 3\u2009T clinical PET\/MR system. To enable volumetric coverage, the sinusoidal shaped readout gradients per k\u2010t\u2010spoke were rotated along the three spatial dimensions in a golden\u2010angle like manner. A distance\u2010weighted, density\u2010compensated gridding reconstruction was used, also in cases with undersampling of spokes in k\u2010space. Measurements without and with HP <jats:sup>13<\/jats:sup>C\u2010labeled substances were performed in phantoms and rats using a double\u2010resonant <jats:sup>13<\/jats:sup>C\/<jats:sup>1<\/jats:sup>H volume resonator with 72\u2009mm inner diameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Phantom measurements demonstrated the feasibility of the implemented rEPSI sequence, as well as the robustness to undersampling in k\u2010space up to a factor of 5 without advanced reconstruction techniques. Applied to measurements with HP [1\u2010<jats:sup>13<\/jats:sup>C]pyruvate in a tumor\u2010bearing rat, we obtained well\u2010resolved MRSI datasets with a large matrix size of 12<jats:sup>3<\/jats:sup> voxels covering the whole imaging FOV of (180\u2009mm)<jats:sup>3<\/jats:sup> within 6.3\u2009s, enabling to observe metabolism in dynamic acquisitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After further optimization, the proposed rEPSI method may be useful in applications of HP <jats:sup>13<\/jats:sup>C\u2010tracers where unknown or varying metabolite resonances are expected, and the acquisition of dynamic, volumetric MRSI datasets with an adequate temporal resolution is a challenge.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30258","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T01:29:42Z","timestamp":1724290182000},"page":"31-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Three\u2010dimensional radial echo\u2010planar spectroscopic imaging for hyperpolarized <scp><sup>13<\/sup>C MRSI<\/scp> in vivo"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0656-6537","authenticated-orcid":false,"given":"Marcel","family":"Awenius","sequence":"first","affiliation":[{"name":"Division of Medical Physics in Radiology German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Faculty of Physics and Astronomy University of Heidelberg  Heidelberg Germany"},{"name":"Max\u2010Planck\u2010Institute for Nuclear Physics  Heidelberg 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