{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:12:33Z","timestamp":1785186753179,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To develop a robust 3D ultrashort\u2010TE (UTE) protocol that can reproducibly provide high\u2010quality images, assessed by the ability to yield clinically diagnostic images, and is suitable for clinical translation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Theory and Methods<\/jats:title><jats:p>Building on previous work, a UTE sampled with Fermat looped orthogonally encoded trajectories (FLORET) was chosen as a starting point due to its shorter, clinically reasonable scan times. Modifications to previous FLORET implementations included gradient waveform frequency limitations, a new trajectory ordering scheme, a balanced SSFP implementation, fast gradient spoiling, and full inline reconstruction. FLORET images were collected in phantoms and humans on multiple scanners and sites to demonstrate these improvements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The updates to FLORET provided high\u2010quality images in phantom, musculoskeletal, and pulmonary applications. The gradient waveform modifications and new trajectory ordering scheme significantly reduced visible artifacts. Fast spoiling reduced acquisition time by 20%\u201328%. Across the various scanners and sites, the inline image quality was consistent and of diagnostic quality. Total image acquisition plus reconstruction time was less than 4\u2009min for musculoskeletal and pulmonary applications with reconstructions taking less than 1 min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recently developed improvements for the FLORET sequence have enabled robust, high\u2010quality UTE acquisitions with short acquisition and reconstruction times. This enables clinical UTE imaging as demonstrated by the implementation of the sequence and acquisition on five MRI scanners, at three different sites, without the need for any additional system characterization or measurements.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30277","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T06:46:02Z","timestamp":1725259562000},"page":"276-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["High\u2010quality <scp>FLORET UTE<\/scp> imaging for clinical translation"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4356-9622","authenticated-orcid":false,"given":"Matthew M.","family":"Willmering","sequence":"first","affiliation":[{"name":"Center for Pulmonary Imaging Research, Division of Pulmonary Medicine Cincinnati Children's Hospital  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati School of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-8645","authenticated-orcid":false,"given":"Guruprasad","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Philips Healthcare  Rochester Minnesota USA"},{"name":"Department of Radiology University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan K.","family":"Robison","sequence":"additional","affiliation":[{"name":"Philips Healthcare  Nashville Tennessee USA"},{"name":"Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens T.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Advanced Magnetic Resonance Imaging and Spectroscopy Facility, McKnight Brain Institute University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Woods","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Division of Pulmonary Medicine Cincinnati Children's Hospital  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati School of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Pipe","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Wisconsin\u2013Madison  Madison Wisconsin USA"},{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28312"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27583"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22918"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26500"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17582-w"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27800"},{"key":"e_1_2_8_8_1","unstructured":"KrishnamoorthyG WillmeringMM WoodsJC PipeJG.High\u2010quality lung imaging with FLORET UTE and Fibonacci interleaved trajectory ordering.In: Proceedings of the Annual Meeting of ISMRM 2022 London UK."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28566"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28272"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24675"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25841"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27902"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29312"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28993"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-023-01089-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27147"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2021.106977"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22898"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28449"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28119"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21237"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23041"},{"key":"e_1_2_8_24_1","unstructured":"AlbusK.Clinical Image Testing: MRI. 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