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Keyhole reconstruction\u2010based RBC signal oscillation amplitude mapping was applied retrospectively to data acquired from 28 healthy volunteers, 4 chronic thromboembolic pulmonary hypertension (CTEPH) patients, and 5 patients who were hospitalized due to COVID\u201019 pneumonia and had residual lung abnormalities. Using a sliding window keyhole reconstruction, maps of RBC oscillation amplitude were corrected for regional phase difference. Repeatability of the phase\u2010adjusted oscillation amplitude was assessed in 8 healthy volunteers across three scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With sliding window keyhole reconstruction, regional phase differences were observed in the RBC signal oscillations: mean phase\u2009=\u2009(0.27\u2009\u00b1\u20090.19) rad in healthy volunteers, (0.24\u2009\u00b1\u20090.13) rad in CTEPH patients, and (0.33\u2009\u00b1\u20090.19) rad in patients with post\u2010COVID\u201019 residual lung abnormality. The oscillation amplitude and phase maps were more heterogeneous (i.e., they showed increased coefficient of variation) for the CTEPH patients. The RBC oscillation amplitude was repeatable, and the mean three\u2010scan coefficient of variation was smaller when the phase adjustment was made (0.07\u2009\u00b1\u20090.04 compared with 0.16\u2009\u00b1\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sliding window keyhole reconstruction of radial dissolved <jats:sup>129<\/jats:sup>Xe imaging reveals regional phase differences in the RBC oscillations, which are not captured when performing two phase keyhole reconstruction. This regional phase information may reflect the hemodynamic effect of the cardiac pulse wave in the pulmonary microvasculature.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30296","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T17:24:01Z","timestamp":1729272241000},"page":"584-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mapping the amplitude and phase of dissolved <scp><sup>129<\/sup>Xe<\/scp> red blood cell signal oscillations with keyhole spectroscopic lung imaging"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5343-2446","authenticated-orcid":false,"given":"Jemima H.","family":"Pilgrim\u2010Morris","sequence":"first","affiliation":[{"name":"POLARIS, Section of Medical Imaging and Technologies, Division of Clinical Medicine, School of Medicine and Population Health University of Sheffield   Sheffield UK"},{"name":"Insigneo 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