{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:47:49Z","timestamp":1790351269196,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["885876"],"award-info":[{"award-number":["885876"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ED2109A"],"award-info":[{"award-number":["01ED2109A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Chemical exchange saturation transfer (CEST) measurements at ultra\u2010high field (UHF) suffer from strong saturation inhomogeneity. Retrospective correction of this inhomogeneity is possible to some extent, but requires a time\u2010consuming repetition of the measurement. Here, we propose a calibration\u2010free parallel transmit (pTx)\u2010based saturation scheme that homogenizes the saturation over the imaging volume, which we call PUlse design for Saturation Homogeneity utilizing Universal Pulses (PUSHUP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Theory<\/jats:title><jats:p>Magnetization transfer effects depend on the saturation . PUSHUP homogenizes the saturation  by using multiple saturation pulses with alternating \u2010shims. Using a database of  maps, universal pulses are calculated that remove the necessity of time\u2010consuming, subject\u2010based pulse calculation during the measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PUSHUP was combined with a whole\u2010brain three\u2010dimensional\u2010echo planar imaging (3D\u2010EPI) readout. Two PUSHUP saturation modules were calculated by either applying whole\u2010brain or cerebellum masks to the database maps. The saturation homogeneity and the group mean CEST amplitudes were calculated for different \u2010correction methods and were compared to circular polarized (CP) saturation in five healthy volunteers using an eight\u2010channel transmit coil at 7 Tesla.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In contrast to CP saturation, where accurate CEST maps were impossible to obtain in the cerebellum, even with extensive \u2010correction, PUSHUP CEST maps were artifact\u2010free throughout the whole brain. A 1\u2010point retrospective \u2010correction, that does not need repeated measurements, sufficiently removed the effect of residual saturation inhomogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presented method allows for homogeneous whole\u2010brain CEST imaging at 7 Tesla without the need of a repetition\u2010based \u2010correction or online pulse calculation. With the fast 3D\u2010EPI readout, whole\u2010brain CEST imaging with 45 saturation offsets is possible at 1.6 mm resolution in under 4 min.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30305","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T09:38:11Z","timestamp":1726825091000},"page":"630-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Calibration\u2010free whole\u2010brain CEST imaging at 7T with parallel transmit pulse design for saturation homogeneity utilizing universal pulses (PUSHUP)"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3907-5494","authenticated-orcid":false,"given":"Yannik","family":"V\u00f6lzke","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Bonn 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