{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:36:36Z","timestamp":1788323796209,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004426","name":"Atlantic Philanthropies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>One possible contributing factor for cerebral blood flow (CBF) decline in normal aging is the increase in partial volume effects due to brain atrophy, as cortical thinning can exacerbate the contamination of gray\u2010matter (GM) voxels by other tissue types. This work investigates CBF changes in normal aging of a large elderly cohort aged 54 to 84 and how correction for partial volume effects that would accommodate potential changes in GM might affect this.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study cohort consisted of 474 participants aged 54 to 84\u2009years using pseudo\u2010continuous arterial spin labeling MRI. A volumetric pipeline and a surface\u2010based pipeline were applied to measure global and regional perfusion. Volumetric regions of interest (ROIs) included GM, cerebral white matter, vascular territories, and the brain atlas from the UK Biobank. The cortical parcellation was using Desikan\u2013Killiany atlas. Non\u2013partial volume effect correction (PVEc) and PVEc GM\u2010CBF changes with aging were modeled using linear regressions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Global GM CBF decreased by 0.17\u2009mL\/100\u2009g\/min per year with aging before PVEc (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and was 0.18\u2009mL\/100\u2009g\/min after PVEc (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). All cortical parcels exhibited CBF decreases with age before PVEc. After PVEc, seven parcels retained decreasing trends. However, GM CBF demonstrated increase with age after PVEc in three parcels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although decreases in global perfusion are observed with aging before PVEc, perfusion variations appear to be more regionally selective after PVEc. This supports the understanding that variation in cerebral perfusion with age observed with imaging is influenced by regional changes in anatomy that can be accommodated with PVEc, but perfusion variation is still observable even after PVE is accounted for.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30376","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T01:40:31Z","timestamp":1732153231000},"page":"1807-1820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Regional changes in cerebral perfusion with age when accounting for changes in gray\u2010matter volume"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0946-9617","authenticated-orcid":false,"given":"Jian","family":"Hu","sequence":"first","affiliation":[{"name":"Mental Health &amp; Clinical Neurosciences, School of Medicine University of Nottingham  Nottingham UK"},{"name":"Sir Peter Mansfield Imaging Center, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Craig","sequence":"additional","affiliation":[{"name":"Mental Health &amp; Clinical Neurosciences, School of Medicine University of Nottingham  Nottingham UK"},{"name":"Sir Peter Mansfield Imaging Center, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvin P.","family":"Knight","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing, School of Medicine Trinity College Dublin  Dublin Ireland"},{"name":"School of Medicine Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"De Looze","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing, School of Medicine Trinity College Dublin  Dublin Ireland"},{"name":"School of Medicine Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Meaney","sequence":"additional","affiliation":[{"name":"School of Medicine Trinity College Dublin  Dublin Ireland"},{"name":"The National Center for Advanced Medical Imaging St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Anne","family":"Kenny","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing, School of Medicine Trinity College Dublin  Dublin Ireland"},{"name":"School of Medicine Trinity College Dublin  Dublin Ireland"},{"name":"The Global Brain Health Institute Trinity College Dublin  Dublin Ireland"},{"name":"Mercer's Institute for Successful Ageing St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Intelligent Modelling &amp; 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