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Simulation results were used to inform the design of VFA sequences, validated in four volunteers for hyperpolarized xenon\u2010129 imaging of the lungs and another four volunteers for hyperpolarized carbon\u201013 imaging of the human brain. B\n                      <jats:sub>1<\/jats:sub>\n                      maps obtained were used to correct transmit and receive inhomogeneity in the images.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Simulations showed improved performance of the VFA approach over the CFA approach with reduced sensitivity to T\n                      <jats:sub>1<\/jats:sub>\n                      . For xenon\u2010129, the B\n                      <jats:sub>1<\/jats:sub>\n                      maps accurately reflected the variation of signal depolarization, but in some cases could not be used to correct for coil receive inhomogeneity due to a lack of transmit\u2010receive reciprocity resulting from suboptimal coil positioning. For carbon\u201013, the B\n                      <jats:sub>1<\/jats:sub>\n                      maps showed good agreement with a separately acquired B\n                      <jats:sub>1<\/jats:sub>\n                      map of a phantom and were effectively used to correct coil\u2010induced signal inhomogeneity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      A simple, versatile, and effective VFA B\n                      <jats:sub>1<\/jats:sub>\n                      mapping method was implemented and evaluated. Inclusion of the B\n                      <jats:sub>1<\/jats:sub>\n                      mapping method in hyperpolarized imaging studies can enable more robust signal quantification.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30378","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T02:20:29Z","timestamp":1731896429000},"page":"1615-1628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of an integrated variable flip angle protocol to estimate coil\n                    <scp>\n                      B\n                      <sub>1<\/sub>\n                    <\/scp>\n                    for hyperpolarized\n                    <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4917-2108","authenticated-orcid":false,"given":"Kylie","family":"Yeung","sequence":"first","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research University of Oxford   Oxford UK"},{"name":"Department of Oncology University of Oxford  Oxford UK"},{"name":"Department of Radiology Oxford University Hospitals  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kher Lik","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Radiology Oxford University Hospitals  Oxford UK"},{"name":"Oxford Respiratory Service Oxford University Hospitals  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan J.","family":"McGing","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research University of Oxford   Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Axford","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research University of Oxford   Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Birkhoelzer","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research University of Oxford   Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Shinozaki","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research University of Oxford   Oxford UK"},{"name":"Department of Physiology, Anatomy, and Genetics University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4430-3843","authenticated-orcid":false,"given":"Mattia","family":"Ricchi","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research University of Oxford   Oxford UK"},{"name":"Department of Computer Sciences University of Pisa  Pisa Italy"},{"name":"National Institute of Nuclear Physics (INFN) Division of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Sgambelluri","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research University of Oxford   Oxford UK"},{"name":"Alma Mater Studorium University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Zaccagna","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research University of Oxford   Oxford UK"},{"name":"Department of Radiology Cambridge University Hospitals  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Mills","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research University of Oxford   Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J. 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