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The fermat\u2010looped orthogonally encoded trajectories (FLORET) sequence addresses these issues with high sampling efficiency, strong signal, and motion robustness, but has not yet been applied to phase\u2010resolved functional lung (PREFUL) MRI\u2014a contrast\u2010free method for assessing pulmonary ventilation during free breathing. This study aims to develop a reconstruction pipeline for FLORET UTE, enhancing spatial resolution for three\u2010dimensional (3D) PREFUL ventilation analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The FLORET sequence was used to continuously acquire data over 7\u2009\u00b1\u20092\u2009min in 36 participants, including healthy subjects (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20097) and patients with various pulmonary conditions (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200929). Data were reconstructed into respiratory images using motion\u2010compensated low\u2010rank reconstruction, and a 3D PREFUL algorithm was adapted to quantify static and dynamic ventilation surrogates. Image sharpness and signal\u2010to\u2010noise ratio were evaluated across different motion states. PREFUL ventilation metrics were compared with static\n                      <jats:sup>129<\/jats:sup>\n                      Xe ventilation MRI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Optimal image sharpness and accurate ventilation dynamics were achieved using 24 respiratory bins, leading to their use in the study. A strong correlation was found between 3D PREFUL FLORET UTE ventilation defect percentages (VDPs) and\n                      <jats:sup>129<\/jats:sup>\n                      Xe VDPs (r\u2009\u2265\u20090.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), although PREFUL FLORET static VDPs were significantly higher (mean bias\u2009=\u2009\u221210.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). In diseased patients, dynamic ventilation parameters showed greater heterogeneity and better alignment with\n                      <jats:sup>129<\/jats:sup>\n                      Xe VDPs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The proposed reconstruction pipeline for FLORET UTE MRI offers improved spatial resolution and strong correlation with\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRI, enabling dynamic ventilation quantification that may reveal airflow abnormalities in lung disease.\n                    <\/jats:p>\n                  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