{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:58:09Z","timestamp":1775487489810,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K07829"],"award-info":[{"award-number":["20K07829"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H01341"],"award-info":[{"award-number":["21H01341"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["K23K06888"],"award-info":[{"award-number":["K23K06888"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Redox homeostasis plays a key role in regulating the overall health and development of organisms. This study aimed to develop a compact and mobile continuous\u2010wave (CW) electron paramagnetic resonance (EPR) imager to facilitate stable, highly sensitive fast three\u2010dimensional (3D)\u00a0whole\u2010body imaging of nitroxide\u2010infused mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multiturn loop gap resonator with a diameter of 30\u2009mm and length of 35\u2009mm was designed for whole\u2010body EPR imaging. A compact and mobile CW\u2010EPR imager operating at 750\u2009MHz was developed using this resonator. The automatic matching and tuning control systems were also adjusted to compensate for perturbations caused by the movement of the mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When the mice were inserted into the resonator, the resonant frequency was easily determined for all parts of the mouse, from the head to the lower abdomen. 3D EPR images of the mouse body from the thoracic region to the lower abdomen were obtained following infusion of a nitroxide, 3\u2010carboxy\u20102,2,5,5\u2010tetramethylpyrrolidine\u20101\u2010oxyl (CxP). The EPR images clearly visualized the CxP distribution in various organs at different concentrations. Time\u2010dependent EPR images also revealed that the signal intensities of the CxP decayed over time, and the decay rates for the heart, liver, and kidneys were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A compact and mobile EPR imager that enables 3D whole\u2010body EPR image of nitroxide in mice was developed. The EPR imager exhibited long\u2010term stability against motion effects caused by respiratory motion and heartbeats in mice. The EPR images clearly visualized the in vivo distribution, clearance, and metabolism of the nitroxide in organs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30432","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T06:00:11Z","timestamp":1737352811000},"page":"424-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Three\u2010dimensional whole\u2010body imaging of the bioreduction and clearance of nitroxide probes in the thoracic and abdominal regions of mice using a compact and mobile electron paramagnetic resonance imager"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-628X","authenticated-orcid":false,"given":"Hideo","family":"Sato\u2010Akaba","sequence":"first","affiliation":[{"name":"Department of Electrical and Electronic Engineering Graduate School of Integrated Science and Technology, Shizuoka University   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