{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:14:24Z","timestamp":1788462864031,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41EB024495"],"award-info":[{"award-number":["P41EB024495"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      We hypothesized that radiation\u2010induced tubulointerstitial changes in the kidney can be assessed using MRI\u2010based T\n                      <jats:sub>2<\/jats:sub>\n                      relaxation time measurements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed MRI, histology, and serum biochemistry in two mouse models of radiation nephropathy: one involving external beam radiotherapy and the other using internal irradiation with an \u03b1\u2010particle\u2010emitting actinium\u2010225 radiolabeled antibody. We compared the mean T\n                      <jats:sub>2<\/jats:sub>\n                      values of different renal compartments between control and external beam radiotherapy or \u03b1\u2010particle\u2010emitting actinium\u2010225 radiolabeled antibody\u2013treated groups and between the two radiation\u2010treated groups using a Wilcoxon rank\u2010sum test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significantly higher T\n                      <jats:sub>2<\/jats:sub>\n                      values were found in the cortex and outer stripe of the outer medulla in all treated animals compared with the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In addition, these changes in T\n                      <jats:sub>2<\/jats:sub>\n                      were observed before any changes in serum parameters, animal body weight, and kidney volume occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      T\n                      <jats:sub>2<\/jats:sub>\n                      mapping is sensitive to radiation\u2010induced tubulointerstitial changes in the kidney.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30443","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T05:39:47Z","timestamp":1737610787000},"page":"251-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["MRI detects tubulointerstitial changes in mouse models of radiation\u2010induced nephropathy"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2730-4250","authenticated-orcid":false,"given":"Julia","family":"Stabinska","sequence":"first","affiliation":[{"name":"F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute   Baltimore Maryland USA"},{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Piccolo","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupriya","family":"Chhabra","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Liatsou","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Gabrielson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Comparative Pathobiology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinia","family":"Mohanta","sequence":"additional","affiliation":[{"name":"F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute   Baltimore Maryland USA"},{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9067-3684","authenticated-orcid":false,"given":"Farzad","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sgouros","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8917-7640","authenticated-orcid":false,"given":"Michael T.","family":"McMahon","sequence":"additional","affiliation":[{"name":"F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute   Baltimore Maryland USA"},{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360\u20103016(91)90171\u2010y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01241"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.058651"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010021\u201001764\u2010y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.98106559"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy181"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy163"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy243"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy180"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy198"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00114.2005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004110945"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424\u2010198601000\u201000002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e31829d0414"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20100978\u20101_36"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.595711"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000054"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162705"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201001895\u2010x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9081071"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360\u20103016(92)90955\u2010H"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2023.02.007"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11971"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20314"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968\u2010015\u20100125\u20101"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.30115"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.30443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T11:24:10Z","timestamp":1762514650000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.30443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/mrm.30443"],"URL":"https:\/\/doi.org\/10.1002\/mrm.30443","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,23]]},"assertion":[{"value":"2024-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}