{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T11:28:27Z","timestamp":1762514907915,"version":"build-2065373602"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10 OD025016"],"award-info":[{"award-number":["S10 OD025016"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U24 NS072026"],"award-info":[{"award-number":["U24 NS072026"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007306","name":"Arizona Department of Health Services","doi-asserted-by":"publisher","award":["211002"],"award-info":[{"award-number":["211002"]}],"id":[{"id":"10.13039\/100007306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008335","name":"Arizona Biomedical Research Commission","doi-asserted-by":"publisher","award":["4001","0011","05\u2010901","1001"],"award-info":[{"award-number":["4001","0011","05\u2010901","1001"]}],"id":[{"id":"10.13039\/100008335","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Double diffusion encoding (DDE) acquisition strategies promise specificity for small\u2010dimensional structures inaccessible to single diffusion encoding (SDE). For DDE\u2010weighted MRI scans to become relevant for whole brain imaging, signal reconstruction frameworks must accurately report microstructural features of interest\u2014especially microscale anisotropy in complex tissue environments. This study examined the recently developed diffusion tensor subspace imaging (DiTSI) framework and its radial and spherical anisotropy metrics (RA and SA, respectively) in postmortem human brain tissue specimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MRI microscopy including multishell SDE\u2010weighted and DDE\u2010weighted imaging was performed for healthy brain stem and temporal lobe specimens and for specimens with Alzheimer's disease pathology and neurodegeneration. The DiTSI framework was compared with four other diffusion MRI frameworks, and angular and radial DDE sampling were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DDE acquisition and the DiTSI metric maps of SA and RA in temporal lobe and brain\u2010stem specimens were found to be distinct from fractional anisotropy and orientation dispersion index in providing complementary and selective contrast of microscale anisotropy at the gray\u2010matter\/white\u2010matter interface in the cortex and in hippocampal layers. DiTSI maps also unmasked small fascicles in the brain stem that were not detectable by SDE techniques and provided selective contrast across the major fiber pathways. Results also revealed prominent reductions of SA and RA in tissue with Alzheimer's disease pathology that were not observed for any other framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>New contrasts were evident for DiTSI framework metrics over a range of tissue environments with promise toward providing novel markers of pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30463","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:40:27Z","timestamp":1741714827000},"page":"2370-2385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffusion tensor subspace imaging of double diffusion\u2013encoded\n                    <scp>MRI<\/scp>\n                    delineates small fibers and gray\u2010matter microstructure not visible with single encoding techniques"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3374-5469","authenticated-orcid":false,"given":"Elizabeth B.","family":"Hutchinson","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Arizona   Tucson Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Philippe","family":"Galons","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging University of Arizona  Tucson Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney J.","family":"Comrie","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Arizona   Tucson Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Beach","sequence":"additional","affiliation":[{"name":"Banner Sun Health Research Institute  Sun City Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geidy E.","family":"Serrano","sequence":"additional","affiliation":[{"name":"Banner Sun Health Research Institute  Sun City Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark W.","family":"Bondi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine University of California San Diego  California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seraphina K.","family":"Solders","sequence":"additional","affiliation":[{"name":"Center for Scientific Computation in Imaging University of California at San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitaly L.","family":"Galinsky","sequence":"additional","affiliation":[{"name":"Center for Scientific Computation in Imaging University of California at San Diego  La Jolla California USA"},{"name":"Institute of Engineering in Medicine 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