{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:10:41Z","timestamp":1781784641933,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\u20102019\u201004505"],"award-info":[{"award-number":["RGPIN\u20102019\u201004505"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To confirm ihMT's specificity to myelin, an ihMT presaturation module was combined with a Poon\u2013Henkelman multi\u2010echo spin\u2010echo readout to separate the ihMT signal in myelin water from intra\u2010\/extra\u2010cellular water. This study explored the relationship between two quantitative myelin imaging techniques and measured the ihMT signal of myelin water.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six rats were injured; three were sacrificed three weeks post\u2010injury, and three were sacrificed eight weeks post\u2010injury, and three healthy control rats were also sacrificed. The nine formalin\u2010fixed rat spinal cords were imaged using a Poon\u2013Henkelman multi\u2010echo spin\u2010echo readout with an ihMT prepulse at different strengths of  filtering at 7T.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The proposed model was able to characterize the ihMT decay signal in myelin water and intra\u2010\/extra\u2010cellular water pool. From this proposed four\u2010pool model with dipolar order reservoirs, we see a drop in the  fit parameter in the fasciculus gracilis white matter region of the three\u2010week post\u2010injury cord.  and (non\u2010myelin) were estimated to be approx. 8 and 1.5 ms, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The drop in  in the three\u2010week post\u2010injury cords suggests that  could potentially distinguish between functional myelin and myelin debris; however, more studies are needed to confirm this.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30465","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T04:41:26Z","timestamp":1739853686000},"page":"278-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interpretation of 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