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Lipid signal was suppressed using a numerically optimized water\u2010excitation RF pulse to reduce lipid streaking artifacts and to improve overall image quality. Optimal acquisition parameters were established for a 5\u2010min scan time using extended phase graph simulations. A compressed sensing\u2010based reconstruction incorporating cardiac and respiratory inter\u2010bin deformation fields was employed to generate 5D images of the whole heart. The sharpness and contrast between the left ventricular blood pool and myocardium, along with the functional measurements of the left ventricle from the 5D datasets, were compared to routine 2D cine imaging in 16 healthy volunteers and three patients referred for clinically indicated CMR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The proposed method resulted in lower contrast  vs.  and sharpness  vs. , but enabled similar left\u2010ventricle ejection fraction assessment , limits of , intraclass correlation  with high reproducibility compared to 2D cine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proposed contrast\u2010free, interrupted free\u2010running 5D imaging provides left ventricular functional assessments comparable to 2D cine at 3\u2009T, while offering an improved patient experience through shorter scan times and free breathing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30469","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T02:42:56Z","timestamp":1741574576000},"page":"2386-2400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Free\u2010running 5D whole\u2010heart MRI for isotropic cardiac function measurements at 3T without contrast agents"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9178-9964","authenticated-orcid":false,"given":"Augustin C.","family":"Ogier","sequence":"first","affiliation":[{"name":"Department of Radiology Lausanne University Hospital (CHUV) and University of Lausanne (UNIL)  Lausanne 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