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This may be particularly true in white matter disorders, including leukodystrophies and multiple sclerosis, in which frequent myelin\u2010sensitive imaging, such as magnetization transfer (MT) imaging, might improve clinical care and patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We implemented an on\u2010resonance approach to MT imaging on a commercial point\u2010of\u2010care 64 mT scanner using a non\u2010balanced steady\u2010state free precession sequence. Phantom and in vivo experiments were used to evaluate and optimize the sequence sensitivity and reproducibility, and to demonstrate in vivo performance and inter\u2010site reproducibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From phantom experiments, T\n                      <jats:sub>1<\/jats:sub>\n                      and T\n                      <jats:sub>2<\/jats:sub>\n                      effects were determined to have a negligible effect on the differential MT weighting. MT ratio (MTR) values in white matter were 23.1\u2009\u00b1\u20091.0% from 10 healthy volunteers, with an average reproducibility coefficient of variation of 1.04%. Normal\u2010appearing white matter MTR values in a multiple sclerosis participant (21.5\u2009\u00b1\u20096.2%) were lower, but with a similar spread of values, compared to an age\u2010matched healthy volunteer (23.3\u2009\u00b1\u20096.2%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An on\u2010resonance MT imaging approach was developed at 64 mT that can be performed in as little as 4\u2009min. A semi\u2010quantitative myelin\u2010sensitive imaging biomarker at this field strength is available for assessing both myelination and demyelination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30494","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T14:53:46Z","timestamp":1742223226000},"page":"602-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Magnetization transfer imaging using non\u2010balanced\n                    <scp>SSFP<\/scp>\n                    at ultra\u2010low field"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6232-8488","authenticated-orcid":false,"given":"Sharada","family":"Balaji","sequence":"first","affiliation":[{"name":"Department of Physics and Astronomy University of British Columbia   Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neale","family":"Wiley","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy University of British Columbia   Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-5610","authenticated-orcid":false,"given":"Adam","family":"Dvorak","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy University of British Columbia   Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Padormo","sequence":"additional","affiliation":[{"name":"Hyperfine Inc.  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