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The optimization included adjusting the inter\u2010RF pulse spacing (TR\n                      <jats:sub>PCASL<\/jats:sub>\n                      ), mean B\n                      <jats:sub>1<\/jats:sub>\n                      <jats:sup>+<\/jats:sup>\n                      (B\n                      <jats:sub>1<\/jats:sub>\n                      <jats:sup>+<\/jats:sup>\n                      <jats:sub>ave<\/jats:sub>\n                      ), slice\u2010selective gradient amplitude (G\n                      <jats:sub>max<\/jats:sub>\n                      ), and mean gradient amplitude (G\n                      <jats:sub>ave<\/jats:sub>\n                      ). In vivo data were acquired from six volunteers at 7\u2009T to validate the optimized parameters. Dynamic B\n                      <jats:sub>0<\/jats:sub>\n                      \u2010shimming and flip angle adjustments were used to avoid needing to make the PCASL parameters robust to B\n                      <jats:sub>0<\/jats:sub>\n                      \/B\n                      <jats:sub>1<\/jats:sub>\n                      <jats:sup>+<\/jats:sup>\n                      variations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The optimized PCASL parameters achieved a significant (3.3\u00d7) reduction in RF power while maintaining high labeling efficiency. This allowed for longer label durations and minimized deadtime, resulting in a 118% improvement in SNR efficiency in vivo compared to a previously proposed protocol. Additionally, the static tissue response was improved, reducing the required distance between labeling plane and imaging volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These optimized PCASL parameters provide a robust and efficient approach for whole brain perfusion imaging at 7\u2009T, with significant improvements in SNR efficiency and reduced specific absorption rate burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30527","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T10:49:13Z","timestamp":1748429353000},"page":"965-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>SNR<\/scp>\n                    \u2010efficient whole\u2010brain pseudo\u2010continuous arterial spin labeling perfusion imaging at 7\u2009T"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0329-824X","authenticated-orcid":false,"given":"Joseph G.","family":"Woods","sequence":"first","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford   Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4134-374X","authenticated-orcid":false,"given":"Yang","family":"Ji","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford   Oxford UK"},{"name":"Department of Electronic Engineering and Information Science, School of Information Science and Technology University of Science and Technology of China  Hefei 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