{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T04:48:53Z","timestamp":1769230133612,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To validate the feasibility of quantitative T<jats:sub>2<\/jats:sub> mapping as a novel, gadolinium\u2010free, preclinical biomarker of interstitial lung disease (ILD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Quantitative T<jats:sub>2<\/jats:sub> mapping of lung parenchyma was obtained with multiple\u2010slice multiple\u2010echo readout. A mono\u2010exponential model of magnetization decay was fit to the data to obtain parametric maps of T<jats:sub>2<\/jats:sub> relaxation time in four slices across whole lungs. The measurements were performed in three clinically relevant murine models ILD: acute lung injury due to endotoxemia, chronic recovery phase post\u2013influenza infection, and bleomycin\u2010induced interstitial lung fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Quantitative maps of T<jats:sub>2<\/jats:sub> relaxation in healthy mice showed a mean value of 10.51\u2009\u00b1\u20090.56\u2009ms. During ILD development, the mean T<jats:sub>2<\/jats:sub> increased up to threefold, showing high sensitivity to altered tissue water content due to augmented fraction of macromolecules in fibrosis or inflammation associated with disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>T<jats:sub>2<\/jats:sub> mapping of mouse lungs can be successfully applied at 9.4\u2009T, offering quantitative insights through parametric T<jats:sub>2<\/jats:sub> mapping across various ILD models without requiring contrast agents. The proposed method for evaluating lung tissue damage is adaptable to other interstitial lung diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30534","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T06:39:42Z","timestamp":1746772782000},"page":"1237-1247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative <scp>T<sub>2<\/sub><\/scp> mapping of lung parenchyma at 9.<scp>4\u2009T<\/scp>: A feasibility study in three murine models of interstitial lung disease"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-3590","authenticated-orcid":false,"given":"Grzegorz","family":"Kwiatkowski","sequence":"first","affiliation":[{"name":"Jagiellonian Centre for Experimental Therapeutics (JCET) Jagiellonian University   Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Kaszlikowska","sequence":"additional","affiliation":[{"name":"M. Smoluchowski Institute of Physics Jagiellonian University  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Seldeslachts","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology, Biomedical MRI Unit\/Molecular Small Animal Imaging Center (MoSAIC) KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Michiels","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology, Biomedical MRI Unit\/Molecular Small Animal Imaging Center (MoSAIC) KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz","family":"Pa\u0142asz","sequence":"additional","affiliation":[{"name":"M. Smoluchowski Institute of Physics Jagiellonian University  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-8895","authenticated-orcid":false,"given":"Uwe","family":"Himmelreich","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology, Biomedical MRI Unit\/Molecular Small Animal Imaging Center (MoSAIC) KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greetje","family":"Vande Velde","sequence":"additional","affiliation":[{"name":"Department of Imaging and Pathology, Biomedical MRI Unit\/Molecular Small Animal Imaging Center (MoSAIC) KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Ch\u0142opicki","sequence":"additional","affiliation":[{"name":"Jagiellonian Centre for Experimental Therapeutics (JCET) Jagiellonian University   Krakow Poland"},{"name":"Faculty of Medicine, Chair of Pharmacology Jagiellonian University Medical College  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/61\/15\/5587"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-022-00866-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-019-0222-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2021.06.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-019-02382-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jimaging8120314"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199905)9:5<699::AID-JMRI12>3.0.CO;2-H"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-015-3751-y"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26891"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27679"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26463"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25849"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25882"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3417"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25999"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25487"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.5105"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26872"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28137"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29756"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3657"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4591"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22645"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","unstructured":"H\u00fcrlimannMD.Optimization of timing in the Carr\u2010Purcell\u2010Meiboom\u2010Gill sequence.2001;19:375\u2010378.","DOI":"10.1016\/S0730-725X(01)00251-X"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166879"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(86)90055-X"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1996.0090"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141894"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-023-02349-z"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22801"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24952"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1109\/JPROC.2009.2026921"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.595535"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.156.3.2991980"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21446"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.2307\/3579521"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390205"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000935"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10082"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27454"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2020.1828070"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9679"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2746"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/RUQ.0000000000000054"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.31"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2020.101836"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000071"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.020321"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP087321"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.30534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T05:39:01Z","timestamp":1752989941000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.30534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,9]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/mrm.30534"],"URL":"https:\/\/doi.org\/10.1002\/mrm.30534","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,9]]},"assertion":[{"value":"2024-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}