{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:47:46Z","timestamp":1790351266018,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore the feasibility of CEST imaging in the human liver at 7\u2009T with  shimming.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      CEST MRI was performed on a 7\u2009T whole\u2010body scanner with a parallel transmission (pTx) system in five healthy volunteers. Static pTx ( shimming) was applied to locally maximize the  magnitude per input power within a given region of interest (ROI) of approximately 30\u2009mm diameter (ROI\n                      <jats:sub>shim<\/jats:sub>\n                      ). Relaxation\u2010compensated inverse magnetization transfer ratio (MTR\n                      <jats:sub>Rex<\/jats:sub>\n                      ) values were quantified for amide protons, guanidino protons, and relayed nuclear Overhauser effect signals based on five\u2010pool Lorentzian fit analysis. MTR\n                      <jats:sub>Rex<\/jats:sub>\n                      values were corrected for B\n                      <jats:sub>1<\/jats:sub>\n                      inhomogeneities using an absolute, accurate MR fingerprinting\u2013based  mapping technique.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Within the ROI\n                      <jats:sub>shim<\/jats:sub>\n                      , reliable MTR\n                      <jats:sub>Rex<\/jats:sub>\n                      values could be calculated for an average of 85% of voxels. The mean MTR\n                      <jats:sub>Rex<\/jats:sub>\n                      values and corresponding coefficient of variations across the group are: 0.113\u2009\u00b1\u20090.009, 8.8% for amide; 0.167\u2009\u00b1\u20090.010, 6.3% for nuclear Overhauser effect; and 0.079\u2009\u00b1\u20090.010, 12.9% for guanidino. MTR\n                      <jats:sub>Rex<\/jats:sub>\n                      values exhibit low variation between subjects, as reflected by low coefficient of variations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this study, we have demonstrated for the first time the feasibility of acquiring and quantifying relaxation\u2010compensated CEST contrasts in the human liver at ultrahigh field. The application of static pTx effectively eliminates  dropouts and allows for accurate CEST contrast quantification within the selected ROI. In addition, the proposed  mapping technique shows efficacy for enhanced MTR\n                      <jats:sub>Rex<\/jats:sub>\n                      B\n                      <jats:sub>1<\/jats:sub>\n                      corrections in the abdomen.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30557","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T06:35:10Z","timestamp":1748068510000},"page":"1604-1615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Human liver\n                    <scp>CEST<\/scp>\n                    imaging at 7\u2009T: Impact of B1+ shimming"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7401-8022","authenticated-orcid":false,"given":"Petr","family":"Bulanov","sequence":"first","affiliation":[{"name":"Division of Medical Physics in Radiology German Cancer Research Center (DKFZ)  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