{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:00:52Z","timestamp":1791874852665,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["NIH P41EB013598"],"award-info":[{"award-number":["NIH P41EB013598"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP180404"],"award-info":[{"award-number":["RP180404"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"Abstract<\/jats:title>\n \n MRI of hyperpolarized (HP) [1\u2010\n 13<\/jats:sup>\n C]pyruvate allows in vivo assessment of metabolism and has translated into human studies across diseases at 15 centers worldwide. To determine consensus on best practice for multi\u2010center studies for development of clinical applications. This paper presents the results of a two\u2010round formal consensus building exercise carried out by experts with HP [1\u2010\n 13<\/jats:sup>\n C]pyruvate human study experience. Twenty\u2010nine participants from 13 sites brought together expertise in pharmacy methods, MR physics, translational imaging, and data analysis with the goal of providing recommendations and best practice statements on conduct of multi\u2010center human studies of HP [1\u2010\n 13<\/jats:sup>\n C]pyruvate MRI. Overall, the group reached consensus on approximately two\u2010thirds of 246 statements in the questionnaire, covering HP\n 13<\/jats:sup>\n C\u2010pyruvate preparation; MRI system setup, calibration, and phantoms; acquisition and reconstruction; and data analysis and quantification. Consensus was present across categories. Examples include: (i) Different HP pyruvate preparation methods could be used in human studies, but the same release criteria have to be followed; (ii) site qualification and quality assurance must be performed with phantoms and the same field strength must be used, but the rest of the system setup and calibration methods could be determined by individual sites; (iii) the same pulse sequence and reconstruction methods were preferable, but the exact choice should be governed by the anatomical target; (iv) normalized metabolite area\u2010under\u2010curve values and metabolite area under curve were the preferred metabolism metrics. The consensus proces revealed that HP[1\u2010\n 13<\/jats:sup>\n C] pyruvate MRI as a technology has progressed sufficiently to plan multi\u2010center studies. The work confirmed areas of consensus for multi\u2010center study conduct and identified where further research is required to ascertain best practice.\n <\/jats:p>","DOI":"10.1002\/mrm.30570","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T08:22:03Z","timestamp":1750148523000},"page":"1386-1400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Consensus recommendations for hyperpolarized [1\u2010\n \n 13<\/sup>\n C\n <\/scp>\n ]pyruvate\n MRI<\/scp>\n multi\u2010center human studies"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-0870","authenticated-orcid":false,"given":"Shonit","family":"Punwani","sequence":"first","affiliation":[{"name":"Department of Radiology University College London Hospital NHS Foundation Trust London UK"},{"name":"Centre for Medical Imaging University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-3634","authenticated-orcid":false,"given":"Peder E. 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