{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:39:17Z","timestamp":1790822357275,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004635","name":"Fru Berta Kamprads Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["21 1910 S"],"award-info":[{"award-number":["21 1910 S"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["22 0592 JIA"],"award-info":[{"award-number":["22 0592 JIA"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["22 2011 Pj"],"award-info":[{"award-number":["22 2011 Pj"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009736","name":"Allm\u00e4nna Sjukhusets i Malm\u00f6 Stiftelse f\u00f6r Bek\u00e4mpande av Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Neglecting imaging gradients in b\u2010value calculations has been a documented issue for decades and remains unaccounted for in the current postprocessing pipelines. This omission may introduce inaccuracies that propagate into diffusion parameter estimates, such as in ADC and DTI analysis. Because intravoxel incoherent motion (IVIM) makes use of low b\u2010values, these inaccuracies may be of greater importance. This study examines the impact of biased b\u2010values on IVIM analysis in simulations and in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In simulations, b\u2010values were calculated for two pulsed gradient spin\u2010echo sequence designs: one with large cross\u2010terms between imaging and diffusion gradients, and one with minimal cross\u2010terms. Biased and unbiased b\u2010values were calculated from sequences with 200 diffusion directions. These b\u2010values were used to generate IVIM signal curves for parameter estimation. Simulations were repeated with varying in\u2010plane resolutions (1\u20134\u2009mm) and slice thicknesses (2\u201310\u2009mm). Additionally, 15 prostate exams were analyzed with scanner\u2010provided b\u2010values and actual b\u2010values derived from the gradient waveforms of the full pulse sequence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The magnitude and direction of errors in IVIM parameters depended on pulse sequence design. Errors persisted until the full contribution of imaging gradients was considered. Errors in the in vivo data were coherent with the simulations, showing errors of \u22120.7% in\n                      <jats:italic>f<\/jats:italic>\n                      , 0.8\u2009\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      \/ms in\n                      <jats:italic>D*<\/jats:italic>\n                      , and 0.07\u2009\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      \/ms in\n                      <jats:italic>D<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ignoring imaging gradients in b\u2010value calculations introduces unnecessary inaccuracies, making IVIM results spurious and highly dependent on specific pulse sequence design and imaging parameters. These inaccuracies can be corrected by adjusting the b\u2010value calculations, without additional measurements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30579","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T01:24:47Z","timestamp":1748913887000},"page":"1514-1528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of inaccurate b\u2010values from imaging gradients on intravoxel incoherent motion"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3704-5803","authenticated-orcid":false,"given":"Ivan A.","family":"Rashid","sequence":"first","affiliation":[{"name":"Department of Translational Medicine, Medical Radiation Physics Lund University   Malm\u00f6 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Sweden"},{"name":"Department of Hematology, Oncology and Radiation Physics Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0455-8904","authenticated-orcid":false,"given":"Patrik","family":"Brynolfsson","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Medical Radiation Physics Lund University   Malm\u00f6 Sweden"},{"name":"Department of Hematology, Oncology and Radiation Physics Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Hero Imaging AB  Ume\u00e5 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