{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:10:00Z","timestamp":1756397400892,"version":"3.44.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62201155"],"award-info":[{"award-number":["62201155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C197\/A16465"],"award-info":[{"award-number":["C197\/A16465"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aims to address the limitation of long acquisition times in luminal water imaging (LWI), a promising noninvasive MRI technique for prostate cancer detection and grading, by implementing an accelerated multi\u2010echo spin\u2010echo method termed T2 mapping using echo merging plus k\u2010t undersampling with reduced flip angles (<jats:italic>TEMPURA)<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>TEMPURA enables faster acquisition through echo merging, <jats:italic>k<\/jats:italic>\u2010t undersampling, and reduced refocusing flip angles. A prospective study was conducted on 24 patients (age 59\u201375\u2009years) with biopsy\u2010proven prostate cancer. Imaging was performed on a 3\u2009T MRI system, comparing two TEMPURA\u2010based LWI sequences\u2014Fast (standard resolution) and High\u2010Resolution (HR, doubled spatial resolution)\u2014against a standard LWI sequence (Standard). Luminal water fraction and five additional parameters were compared across the methods. Statistical analyses included Spearman rank correlation, Wilcoxon rank sum test, receiver operating characteristic analysis, Bland\u2013Altman plots, and Delong tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to Standard, Fast reduced the acquisition time from 8.3 to 2.8\u2009min, whereas HR reduced it to 5.4\u2009min and doubled spatial resolution. Both Fast and HR showed high correlation with Standard for luminal water fraction (<jats:italic>r<\/jats:italic>\u2009=\u20090.97\/0.90 in peripheral zone, <jats:italic>r<\/jats:italic>\u2009=\u20090.91\/0.93 in transition zone), with low bias (0.014\/0.018 in peripheral zone, 0.024\/0.024 in transition zone) and no significant differences (<jats:italic>p<\/jats:italic>\u2009=\u20090.05\u20130.84\/0.08\u20130.51). No significant difference was observed in area under the curve values between Fast\/HR and Standard among all parameters (<jats:italic>p<\/jats:italic>\u2009=\u20090.05\u20130.87).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The acceleration method greatly reduced the acquisition time and increased the spatial resolution of LWI. Compared with the Standard acquisition, both the Fast and HR methods showed a high correlation for LWI measurements and consistent diagnostic performance in detecting malignant lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30628","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T01:20:03Z","timestamp":1751678403000},"page":"2150-2157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fast and High\u2010Resolution luminal water imaging for prostate cancer diagnosis"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7712-0890","authenticated-orcid":false,"given":"Hao","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence Fudan University   Shanghai People's Republic of China"},{"name":"Department of Radiology University of Cambridge  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4500-9714","authenticated-orcid":false,"given":"Nikita","family":"Sushentsev","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Cambridge  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1813-1039","authenticated-orcid":false,"given":"Dimitri","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Cambridge  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence Fudan University   Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang\u2010Lung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Cambridge  Cambridge United Kingdom"},{"name":"Department of Radiology Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9771-4290","authenticated-orcid":false,"given":"Andrew Nicholas","family":"Priest","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Cambridge  Cambridge United Kingdom"},{"name":"Department of Radiology Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4784-5230","authenticated-orcid":false,"given":"Ferdia A.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Cambridge  Cambridge United Kingdom"},{"name":"Department of Radiology Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Cambridge  Cambridge United Kingdom"},{"name":"Department of Radiology Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019181749"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201013\u20103534"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018171130"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017161687"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26597"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27050"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25624"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26608"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21534"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27372"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22756"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25161"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26083"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27707"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28199"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/ad5bb8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22047"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22634"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25972"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","unstructured":"MekleR LaineAF WuEX.Combined MR data Acquisition of Multicontrast.2003;22:806\u2010823.","DOI":"10.1109\/TMI.2003.815054"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.30115"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.58530\/2023\/1289"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21757"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zemedi.2020.04.001"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20102364(88)90128\u2010X"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29282"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.05.035"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968\u2010015\u20100127\u2010z"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968\u2010015\u20100177\u20102"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010020\u201007336\u20100"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010020\u201007256\u2010z"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.30628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T15:51:43Z","timestamp":1756396303000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.30628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/mrm.30628"],"URL":"https:\/\/doi.org\/10.1002\/mrm.30628","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"type":"print","value":"0740-3194"},{"type":"electronic","value":"1522-2594"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"2025-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}