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In this work, we establish a novel MRI approach that enables artifact\u2010free, quiet, simultaneous fMRI of both brain and spinal cord, avoiding the need for dynamic shimming procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used zero TE Multi\u2010Band\u2010SWeep Imaging with Fourier Transformation (MB\u2010SWIFT) technique at 9.4\u2009T in a simultaneous dual\u2010FOV configuration and two separate RF transmit\u2010receive surface coils. The first coil covered the rat brain, while the second was positioned approximately at the T13\u2010L1 level of the rat's spinal cord with copper shielding to minimize the coupling between the RF coils. Eight Sprague\u2013Dawley rats were used for hindlimb stimulation fMRI studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Robust and specific activations were detected in both the brain and spinal cord during hindlimb stimulation at individual and group levels. The results established the feasibility of the novel approach for simultaneous functional assessment of the lumbar spinal cord and brain in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrated the feasibility of a novel dual\u2010FOV fMRI approach based on zero\u2010TE MB\u2010SWIFT and set the stage for translation to humans. The methodology enables comprehensive functional CNS evaluations of great value in different conditions such as pain, spinal cord injury, neurodegenerative diseases, and aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30633","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T19:00:01Z","timestamp":1752778801000},"page":"2335-2346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Simultaneous zero echo time\n                    <scp>fMRI<\/scp>\n                    of rat brain and spinal cord"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1142-9008","authenticated-orcid":false,"given":"Hanne","family":"Laakso","sequence":"first","affiliation":[{"name":"A. I. 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Virtanen Institute for Molecular Sciences University of Eastern Finland   Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2365-865X","authenticated-orcid":false,"given":"Ekaterina","family":"Paasonen","sequence":"additional","affiliation":[{"name":"A. I. Virtanen Institute for Molecular Sciences University of Eastern Finland   Kuopio Finland"},{"name":"Kuopio University Hospital, Neurocenter  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Kettunen","sequence":"additional","affiliation":[{"name":"A. I. Virtanen Institute for Molecular Sciences University of Eastern Finland   Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1950-1828","authenticated-orcid":false,"given":"Russell L.","family":"Lagore","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Deptartment of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"DeLabarre","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Deptartment of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Polcyn","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Deptartment of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6428-9005","authenticated-orcid":false,"given":"Gregor","family":"Adriany","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Deptartment of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ist\u00fariz","sequence":"additional","affiliation":[{"name":"Neos Biotec  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dee M.","family":"Koski","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Deptartment of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0942-3208","authenticated-orcid":false,"given":"Djaudat","family":"Idiyatullin","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Deptartment of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Gr\u00f6hn","sequence":"additional","affiliation":[{"name":"A. 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