{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:54:23Z","timestamp":1791906863085,"version":"4.3.4"},"reference-count":77,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010EB030497"],"award-info":[{"award-number":["R01\u2010EB030497"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>Design a b<\/jats:italic>\u2010value, first\u2010order motion moment (M<\/jats:italic>1<\/jats:italic><\/jats:sub>), and echo time (TE)\u2013optimized data acquisition for simultaneous intravoxel incoherent motion (IVIM) and R<\/jats:italic>2<\/jats:italic><\/jats:sub> quantification in the liver.<\/jats:p><\/jats:sec>Methods<\/jats:title>The b<\/jats:italic>\u2010M<\/jats:italic>1<\/jats:italic><\/jats:sub>\u2010optimized (i.e., single TE) and b<\/jats:italic>\u2010M<\/jats:italic>1<\/jats:italic><\/jats:sub>\u2010TE<\/jats:italic>\u2010optimized (i.e., multi\u2010TE) IVIM acquisitions were determined using Cramer\u2010Rao lower\u2010bound optimization. Eleven healthy volunteers underwent MRI of the liver where each optimized acquisition was acquired twice (test\u2013retest). For each data set, IVIM estimates (diffusion coefficient [D<\/jats:italic>], perfusion signal fractions [f<\/jats:italic>1<\/jats:italic><\/jats:sub> and f<\/jats:italic>2<\/jats:italic><\/jats:sub>], blood velocity standard deviations [SDs] [V<\/jats:italic>b1<\/jats:italic><\/jats:sub> and V<\/jats:italic>b2<\/jats:italic><\/jats:sub>], and\/or relaxation rates of tissue and blood [R<\/jats:italic>2t<\/jats:italic><\/jats:sub> and R<\/jats:italic>2b<\/jats:italic><\/jats:sub>]) were obtained in the right and left liver lobes within distinct spatial locations associated with slow (f<\/jats:italic>1<\/jats:italic><\/jats:sub> and V<\/jats:italic>b1<\/jats:italic><\/jats:sub>) and fast (f<\/jats:italic>2<\/jats:italic><\/jats:sub> and V<\/jats:italic>b2<\/jats:italic><\/jats:sub>) microvascular flow. Six R2<\/jats:sub>\u2010correction methods using combinations of estimated and\/or fixed values of R<\/jats:italic>2t<\/jats:italic><\/jats:sub> and R<\/jats:italic>2b<\/jats:italic><\/jats:sub> were performed. Test\u2013retest repeatability and interlobar agreement were evaluated using coefficients of variation (CVs) and relative mean differences (rMDs).<\/jats:p><\/jats:sec>Results<\/jats:title>The b<\/jats:italic>\u2010M<\/jats:italic>1<\/jats:italic><\/jats:sub>\u2010TE<\/jats:italic>\u2010optimized acquisition demonstrated acceptable to excellent right\u2010lobe test\u2013retest repeatability (CV\u2009=\u20094.58%, 8.94%, 8.62%, 27.5%, 18.8%, 2.85%, and 17.7% for D<\/jats:italic>, V<\/jats:italic>b1<\/jats:italic><\/jats:sub>, V<\/jats:italic>b2<\/jats:italic><\/jats:sub>, f<\/jats:italic>1<\/jats:italic><\/jats:sub>, f<\/jats:italic>2<\/jats:italic><\/jats:sub>, R<\/jats:italic>2t<\/jats:italic><\/jats:sub>, and R<\/jats:italic>2b<\/jats:italic><\/jats:sub>, respectively) and interlobar agreement (|rMD|\u2009=\u20098.82%, 1.84%, 8.72%, 3.08%, and 0.20% for D<\/jats:italic>, V<\/jats:italic>b1<\/jats:italic><\/jats:sub>, V<\/jats:italic>b2<\/jats:italic><\/jats:sub>, R<\/jats:italic>2t<\/jats:italic><\/jats:sub>, and R<\/jats:italic>2b<\/jats:italic><\/jats:sub>, respectively), except for interlobar agreement of f<\/jats:italic>1<\/jats:italic><\/jats:sub> and f<\/jats:italic>2<\/jats:italic><\/jats:sub> (rMD\u2009\u2265\u200937.7%). For the b\u2010M1<\/jats:sub>\u2010optimized acquisition, R<\/jats:italic>2<\/jats:italic><\/jats:sub> correction of f<\/jats:italic>1<\/jats:italic><\/jats:sub> and f<\/jats:italic>2<\/jats:italic><\/jats:sub> provided similar estimates as the b<\/jats:italic>\u2010M<\/jats:italic>1<\/jats:italic><\/jats:sub>\u2010TE<\/jats:italic>\u2010optimized acquisition (|MD|\u2009\u2264\u20091.98%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The b<\/jats:italic>\u2010M<\/jats:italic>1<\/jats:italic><\/jats:sub>\u2010TE<\/jats:italic>\u2010optimized IVIM acquisition enabled simultaneous and repeatable IVIM and R<\/jats:italic>2<\/jats:italic><\/jats:sub> quantification in the liver. For single\u2010TE IVIM data, R<\/jats:italic>2<\/jats:italic><\/jats:sub> correction of f<\/jats:italic> estimates using fixed values of R<\/jats:italic>2t<\/jats:italic><\/jats:sub> and R<\/jats:italic>2b<\/jats:italic><\/jats:sub> may be acceptable.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.70005","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T08:55:33Z","timestamp":1753174533000},"page":"2388-2404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Optimized acquisition for simultaneous intravoxel incoherent motion and R2<\/sub><\/scp> quantification in the liver"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9326-7203","authenticated-orcid":false,"given":"Gregory","family":"Simchick","sequence":"first","affiliation":[{"name":"Radiology University of Wisconsin\u2010Madison Madison Wisconsin 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