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In DIR\u2010preparations, the FAIR\u2010inversion pulses were immediately followed by an identical reinversion pulse, applied either slice\u2010selectively or nonselectively. Bloch\u2010equation\u2010based simulation and phantom experiments were performed to evaluate the PN and SNR across a range of HR variabilities. Data from six healthy subjects were acquired to evaluate myocardial blood flow (MBF), PN, and SNR in vivo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Simulation experiments showed that the average MBF values remained nearly constant across the range of HR variabilities and were comparable across all three sequences. However, DIR\u2010labeling allowed for greater recovery of the myocardial background signal, which mitigates the sensitivity to HR\u2010dependent changes in the inversion time. Consequently, PN in the presence of HR variability was substantially reduced with DIR\u2010labeling. For HR variabilities corresponding to the mean value observed in vivo, this resulted in a simulated SNR gain of 1.79  0.90 for selective and 1.55  0.77 for nonselective DIR\u2010labeling. In vivo, DIR\u2010labeling showed reduced PN, with 53% ()\/44% () less PN compared with conventional FAIR\u2010myoASL, leading to an average SNR gain of 1.47  0.63 ()\/1.32  0.57 () with selective\/nonselective reinversions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proposed DIR\u2010preparations reduce sensitivity to HR variations and alleviate PN in double ECG\u2010gated myoASL, improving the precision of myoASL\u2010based perfusion quantification.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.70018","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T07:27:08Z","timestamp":1754897228000},"page":"2460-2474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myocardial Arterial Spin Labeling with Double Inversion Recovery for reduced physiological 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