{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:35:51Z","timestamp":1790422551751,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n \n Multiparametric arterial spin labeling (MP\u2010ASL) using delays alternating with nutation for tailored excitation (DANTE) pulse (MP\u2010ASL\n DANTE<\/jats:sub>\n ) can noninvasively quantify arterial cerebral blood volume (CBV\n a<\/jats:sub>\n ) and the residence time of labeled spins in the microvascular compartment (\u0394TT). We hypothesized that MP\u2010ASL\n DANTE<\/jats:sub>\n could identify the early stages of hemodynamic impairment in patients with moyamoya disease (MMD) by detecting autoregulatory vasodilation, specifically the elevation of CBV\n a<\/jats:sub>\n . However, the clinical relevance of MP\u2010ASL\n DANTE<\/jats:sub>\n has not yet been fully evaluated. Therefore, we compared MP\u2010ASL\n DANTE<\/jats:sub>\n with [\n 15<\/jats:sup>\n O]H\n 2<\/jats:sub>\n O positron emission tomography (PET) to assess its clinical relevance in patients with MMD.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n MP\u2010ASL\n DANTE<\/jats:sub>\n was performed on 11 patients, and the parameters were estimated using simulation\u2010based deep neural networks. Furthermore, cerebrovascular reactivity (CVR) was calculated from the cerebral blood flow (CBF) before and after acetazolamide challenge using [\n 15<\/jats:sup>\n O]H\n 2<\/jats:sub>\n O PET. Spearman's correlation analyses and group comparisons were performed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Although CBV\n a<\/jats:sub>\n (\u03c1\u2009=\u20090.0288;\n p<\/jats:italic>\n \u2009=\u20090.6876) did not significantly correlate with PET\u2010CVR, \u0394TT showed a significant correlation with PET\u2010CVR (\u03c1\u2009=\u2009\u22120.2599;\n p<\/jats:italic>\n \u2009=\u20090.0002). Moreover, CBV\n a<\/jats:sub>\n could not differentiate between the normal and reduced CVR groups, regardless of the CBF conditions. However, within the normal CBF group, the reduced CVR group exhibited a significantly longer \u0394TT than the normal CVR group (\n p<\/jats:italic>\n \u2009=\u20090.0069), suggesting its capability to differentiate CVR conditions even under normal CBF conditions.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The comprehensive use of MP\u2010ASL\n DANTE<\/jats:sub>\n parameters enables a detailed noninvasive evaluation of cerebral hemodynamics in patients with MMD and potentially allows for the detection of early stages of hemodynamic impairment in these patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mrm.70045","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T04:14:33Z","timestamp":1756527273000},"page":"506-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison between multiparametric arterial spin labeling and [\n \n 15<\/sup>\n O\n <\/scp>\n ]\n \n H\n 2<\/sub>\n O\n <\/scp>\n positron emission tomography in patients with moyamoya disease"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-8057","authenticated-orcid":false,"given":"Shota","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Radiological Technology Faculty of Medical Sciences, Kyoto University of Medical Science Kyoto Japan"},{"name":"Department of Radiology Faculty of Medical Sciences, University of Fukui Fukui Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, University of Fukui Fukui Japan"},{"name":"Radiology Section National Health Insurance Echizen\u2010cho Ota Hospital Fukui Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Isozaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Division of Medicine 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