{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:02:28Z","timestamp":1775617348127,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016342","name":"Ministry of Health Mexico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22mk0101179"],"award-info":[{"award-number":["JP22mk0101179"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study investigated the effect of bicuspid aortic valve (BAV) morphology and ascending aortic curvature (AAAc) bending angles on aortic hemodynamics, focusing on transvalvular jets and secondary helical flows that contribute to systolic hemodynamic stress linked to aortic complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using an MRI\u2010compatible pulsatile flow and pressure system, 24 configurations involving six aortic valves (three Type 1 asymmetric BAVs, two Type 0 symmetric BAVs, and one tricuspid aortic valve [TAV]) across four ascending aortic morphologies\u2014two diameters (30\u2009mm and 40\u2009mm) and two AAAc angles (130\u00b0 and 109\u00b0)\u2014were analyzed through four\u2010dimensional\u2010flow MRI measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three Type 1 BAVs displayed highly deviated transvalvular jets directed toward the aortic wall on the side of the nonfused cusp. Particularly, the right\u2010noncoronary and left\u2010noncoronary cusp fusion phenotypes exhibited markedly eccentric secondary helical flows, thereby increasing hemodynamic stress on the ascending aortic wall. A narrower AAAc further amplified these effects by elevating jet velocity and circulation. Conversely, Type 0 BAVs and TAV were suggested to have lower hemodynamic forces, characterized by less\u2010deviated jets and reduced secondary helical flow eccentricity. Aortic dilation, while enhancing secondary flow circulation, appeared to reduce eccentricity, suggesting a compensatory mechanism in response to altered hemodynamics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of the position of the nonfused cusp and AAAc emerges as a critical determinant of secondary helical flow eccentricity and circulation during peak\u2010to\u2010late systole. The risk assessment based on these hemodynamic parameters offers a novel strategy for identifying individuals at elevated risk of future aortic events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70064","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T10:02:36Z","timestamp":1756807356000},"page":"411-429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In vitro characterization of hemodynamics in bicuspid aortic valves: The impact of valve and ascending aortic morphologies"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6422-2671","authenticated-orcid":false,"given":"Kaoru","family":"Hattori","sequence":"first","affiliation":[{"name":"Department of Integrative Bioscience and Biomedical Engineering, Graduate School of Advanced Science and Engineering Waseda University   Tokyo Japan"},{"name":"Cooperative Major in Advanced 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