{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:52:07Z","timestamp":1765043527521,"version":"3.46.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB033307","R01EB030470","R01EB035091"],"award-info":[{"award-number":["R01EB033307","R01EB030470","R01EB035091"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n \n Accurate targeting during\n MR<\/jats:styled-content>\n \u2010guided focused ultrasound (\n FUS<\/jats:styled-content>\n ) procedures is essential for effective treatment to be achieved. However, spatial discrepancies frequently arise between the planned target and the observed thermal hotspot on proton resonance frequency (\n PRF<\/jats:styled-content>\n )\u2010based\n MR<\/jats:styled-content>\n thermometry because of temperature\u2010induced artifacts. This study aims to correct such displacements caused by chemical shift and k\u2010space center offset.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Spatial misregistration was addressed using a two\u2010step correction approach. The first step corrected pixel\u2010wise displacements attributed to temperature\u2010dependent resonance frequency shifts (chemical shift), based on local frequency offset maps. The second step compensated for\n TE<\/jats:styled-content>\n errors induced by asymmetric phase gradients near the thermal focus, restoring accuracy in hotspot localization. Validation was performed in controlled phantom experiments, and the approach was retrospectively tested in vivo, in 121 sonications across seven essential tremor (\n ET<\/jats:styled-content>\n ) patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Phantom experiments demonstrated that spatial shifts up to approximately 1.5\u2009mm could be effectively corrected. Clinical analysis showed a strong correlation (\n \n R\n 2<\/jats:sup>\n <\/jats:styled-content>\n \u2009=\u20090.852) between temperature rise and spatial displacement, with a mean shift of 0.5\u2009Mm per 10\u00b0C. Combined correction significantly reduced temperature estimation bias, with the mean error decreasing from \u22120.11\u00b0C to \u22120.05\u00b0C, as evaluated by Bland\u2013Altman analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Temperature\u2010related chemical shift and k\u2010space offset substantially impact the spatial fidelity of\n PRF<\/jats:styled-content>\n \u2010based\n MR<\/jats:styled-content>\n thermometry. The proposed correction framework improves thermal hotspot localization, enabling more accurate lesion targeting during\n FUS<\/jats:styled-content>\n procedures.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mrm.70089","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T18:30:19Z","timestamp":1758738619000},"page":"951-961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Focus correction in\n MR<\/scp>\n thermography for increased targeting precision during focused ultrasound procedures"],"prefix":"10.1002","volume":"95","author":[{"given":"Chang\u2010Sheng","family":"Mei","sequence":"first","affiliation":[{"name":"Department of Physics Soochow University Taipei Taiwan"},{"name":"Department of Radiology Mass General Brigham, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4263-4947","authenticated-orcid":false,"given":"Shenyan","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Radiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China"},{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-8771","authenticated-orcid":false,"given":"Bruno","family":"Madore","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham, Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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