{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T03:04:09Z","timestamp":1763780649848,"version":"3.45.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["#453989101"],"award-info":[{"award-number":["#453989101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Cardiac inflammation plays a key role in many diseases. However, its underlying mechanisms and progression remain poorly understood. Using an ultra\u2010high field (UHF) may increase the sensitivity of MRI of inflammatory processes with\n                      <jats:sup>19<\/jats:sup>\n                      F\u2010labeled immune cells. The high Larmor frequency of\n                      <jats:sup>19<\/jats:sup>\n                      F (\u223c95% of that for\n                      <jats:sup>1<\/jats:sup>\n                      H\u2010nuclei) leads to similar technical hurdles in acquiring MR images at UHF that originate from the heterogeneity of B\n                      <jats:sub>1<\/jats:sub>\n                      <jats:sup>+<\/jats:sup>\n                      . We aimed to develop a system of transmit\/receive (Tx\/Rx) arrays exploiting parallel transmit (pTX) technology for B\n                      <jats:sub>1<\/jats:sub>\n                      <jats:sup>+<\/jats:sup>\n                      \u2010shimming to acquire a combination of high\u2010quality anatomical\n                      <jats:sup>1<\/jats:sup>\n                      H MR\u2010images of a pig heart and\n                      <jats:sup>19<\/jats:sup>\n                      F images of labeled immune cells at 7T.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      The 16\u2010element twin\u2010arrays for\n                      <jats:sup>1<\/jats:sup>\n                      H and\n                      <jats:sup>19<\/jats:sup>\n                      F nuclei were designed using electromagnetic simulations with a focus on optimal B\n                      <jats:sub>1<\/jats:sub>\n                      \u2010shimming and g\u2010factor in the region of the pig heart. pTX support allows for the subject\u2010specific B\n                      <jats:sub>1<\/jats:sub>\n                      \u2010shimming for\n                      <jats:sup>1<\/jats:sup>\n                      H cardiac MRI and transfer of settings for the B\n                      <jats:sub>1<\/jats:sub>\n                      \u2010shimming to the\n                      <jats:sup>19<\/jats:sup>\n                      F twin\u2010array.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The twin\u2010array system was implemented and tested in a pig\u2010thorax\u2010\u2010shaped phantom, in\u2010vivo in a myocardial infarction pig model, and in an excised heart. A transfer of static B\n                      <jats:sub>1<\/jats:sub>\n                      + shimming setting between the\n                      <jats:sup>1<\/jats:sup>\n                      H to\n                      <jats:sup>19<\/jats:sup>\n                      F arrays was demonstrated. The parallel imaging acceleration of up to a factor 4 was possible with a g\u2010factor &lt;1.3 for both arrays. The 7T MRI of\n                      <jats:sup>19<\/jats:sup>\n                      F\u2010labeled immune cells in the heart of the pig was demonstrated both in\u2010vivo and ex\u2010vivo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The 7T MRI of perfluorocarbon\u2010labeled immune cells in a large\u2010animal myocardial infarction model becomes feasible using a novel dedicated twin\u2010arrays system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70105","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:25:18Z","timestamp":1760095518000},"page":"51-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>\n                      7T\n                      <sup>19<\/sup>\n                      F\n                    <\/scp>\n                    \/\n                    <scp>\n                      <sup>1<\/sup>\n                      H MRI\n                    <\/scp>\n                    with perfluorocarbon\u2010labeled immune cells in pigs: Pilot results with a dedicated twin\u2010array system with\n                    <scp>pTX<\/scp>\n                    support"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5617-7751","authenticated-orcid":false,"given":"Maxim","family":"Terekhov","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Imaging, Chair of Molecular and Cellular Imaging, Comprehensive Heart Failure Center University Hospital W\u00fcrzburg   W\u00fcrzburg Germany"},{"name":"Chair of Molecular and Cellular Imaging Julius Maximillians\u2010University  W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0408-2942","authenticated-orcid":false,"given":"Ibrahim 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