{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:29:54Z","timestamp":1782134994721,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA269234"],"award-info":[{"award-number":["R01 CA269234"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB004031"],"award-info":[{"award-number":["R01 EB004031"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB036124"],"award-info":[{"award-number":["R01 EB036124"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>In vivo electron paramagnetic resonance (EPR) oximetry is a powerful method for tissue oxygen measurements. OxyChip is an implantable probe that is widely used in animal models and currently being evaluated for use in human subjects. The OxyChip requires an external resonator (RF coil) capable of sufficient depth sensitivity, preferably up to 4\u2009cm or more, which is a limitation for existing resonators. The goal of present study was to develop a novel sensor\/device, called OxyTrack, for deep\u2010tissue oximetry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Several OxyTracks consisting of coax\u2010tip micro\u2010loop resonator embedded with OxyChip were designed using various needles (0.5\u20131\u2009mm outer diameter; 3\u201317\u2009cm length) and tested using an L\u2010band continuous wave EPR spectrometer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The OxyTrack showed high signal\u2010to\u2010noise ratio (SNR) at low RF powers, for example SNR of 86 at 45\u2010nW incident power. The orientation of the sensor with respect to the magnetic field (\n                      <jats:italic>B<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      ) or the depth of insertion into tissue had no significant effect on the measured oxygen values. OxyTrack demonstrated quick response to dynamic changes in oxygen levels and stability to sterilization by autoclaving and ionizing radiation. In vivo measurements in tumor\u2010bearing mouse demonstrated differences in tissue oxygenation in healthy muscle compared to malignant tissues. Compatibility of the OxyTrack with common medical imaging methods was established to register the anatomic location of the sensor in the tissue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The OxyTrack technology represents a significant advancement in the practice of EPR oximetry for in situ monitoring of deep\u2010tissue oxygenation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70121","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T04:40:33Z","timestamp":1764218433000},"page":"1866-1878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>OxyTrack<\/scp>\n                    : A Novel Needle Sensor for In Situ Oximetry"],"prefix":"10.1002","volume":"95","author":[{"given":"Ryan C.","family":"O'Connell","sequence":"first","affiliation":[{"name":"Department of Radiology Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej M.","family":"Kmiec","sequence":"additional","affiliation":[{"name":"Department of Radiology Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V.","family":"Petryakov","sequence":"additional","affiliation":[{"name":"Department of Radiology Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conner S.","family":"Ubert","sequence":"additional","affiliation":[{"name":"Department of Radiology Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"},{"name":"Thayer School of Engineering Dartmouth College  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marthony L.","family":"Robins","sequence":"additional","affiliation":[{"name":"Department of Radiology Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"},{"name":"Thayer School of Engineering Dartmouth College  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Demidenko","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Science Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E.","family":"Schaner","sequence":"additional","affiliation":[{"name":"Department of Radiology Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"},{"name":"Department of Radiation Oncology and Applied Sciences Geisel School of Medicine and Dartmouth\u2010Hitchcock Hospital  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4056-8103","authenticated-orcid":false,"given":"Aharon","family":"Blank","sequence":"additional","affiliation":[{"name":"Schulich Faculty of Chemistry, Technion, Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3214-0660","authenticated-orcid":false,"given":"Periannan","family":"Kuppusamy","sequence":"additional","affiliation":[{"name":"Department of Radiology Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"},{"name":"Thayer School of Engineering Dartmouth College  Hanover New Hampshire USA"},{"name":"Department of Radiation Oncology and Applied Sciences Geisel School of Medicine and Dartmouth\u2010Hitchcock Hospital  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Electron Spin Resonance: A Comprehensive Treatise on Experimental Techniques","author":"Poole C. 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