{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:22:15Z","timestamp":1777569735783,"version":"3.51.4"},"reference-count":93,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["K99EB028828"],"award-info":[{"award-number":["K99EB028828"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Spectral editing is the most common MRS approach for noninvasive in vivo measurement of low\u2010concentration, strongly overlapped metabolites in the brain, such as \u03b3\u2010aminobutyric acid (GABA) and glutathione (GSH). Multi\u2010metabolite editing methods, such as HERMES and HERCULES, enable the editing of multiple\n                      <jats:italic>J<\/jats:italic>\n                      \u2010coupled metabolites in a single acquisition without increasing the total scan time. Yet little is known regarding the reliability of these methods. This study assessed the test\u2013retest reliability of HERMES and HERCULES, where volume localization was achieved using both PRESS and sLASER.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen healthy adult volunteers were scanned twice in two separate sessions. Single\u2010voxel edited MRS data were acquired in the medial parietal lobe using the following sequences: (1) HERMES\u2010PRESS; (2) HERMES\u2010sLASER; (3) HERCULES\u2010PRESS; (4) HERCULES\u2010sLASER. Spectra were processed and metabolites were quantified relative to tCr. Data quality metrics and reliability statistics were estimated for all four acquisitions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HERMES\u2010sLASER produced lower within\u2010subject coefficients of variation (CV\n                      <jats:sub>ws<\/jats:sub>\n                      ) for GABA + co\u2010edited macromolecules (GABA+), GSH, glutamine (Gln),\n                      <jats:italic>myo<\/jats:italic>\n                      \u2010inositol (mI), NAA, and total Cho (tCho), suggesting improved reliability compared to HERMES\u2010PRESS. HERCULES\u2010sLASER produced better reliability than HERCULES\u2010PRESS for GABA+, GSH, aspartate, Gln, lactate, mI, NAA, and tCho with lower CV\n                      <jats:sub>ws<\/jats:sub>\n                      .\n                      <jats:italic>N<\/jats:italic>\n                      \u2010acetylaspartylglutamate (NAAG) showed higher CV\n                      <jats:sub>ws<\/jats:sub>\n                      for HERCULES\u2010sLASER, and Glu showed higher CV\n                      <jats:sub>ws<\/jats:sub>\n                      for HERMES\u2010sLASER and HERCULES\u2010sLASER. Overall, these findings suggest that sLASER yields lower within\u2010subject variability than PRESS for several metabolites for both HERMES and HERCULES, supporting improved measurement reliability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>sLASER yielded better test\u2013retest reliability than PRESS for most metabolites than for multi\u2010metabolite edited MRS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70161","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:24:12Z","timestamp":1761708252000},"page":"1375-1392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Test\u2013Retest Reliability of Multi\u2010Metabolite Edited\n                    <scp>MRS<\/scp>\n                    at\n                    <scp>3T<\/scp>\n 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