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All images were registered to a single target image followed by parameter fitting to generate co\u2010registered T1\/T2\/ADC maps. This approach was evaluated in phantom measurements, 13 healthy volunteers, two myocardial infarction (MI) swine, and two cardiac amyloidosis (CA) patients by comparison to reference mapping techniques. Qualitative assessments were performed by two expert readers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Phantom experiments showed strong agreement with reference measurements (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009&gt;\u20090.96). In volunteers, myocardial T1 values were higher than MOLLI (1341\u2009\u00b1\u200959 vs. 1252\u2009\u00b1\u200936\u2009ms,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003); the proposed T2 values were shorter than T2prep\u2010FLASH (38.7\u2009\u00b1\u20092.2 vs. 41.0\u2009\u00b1\u20092.2\u2009ms;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009), and mean ADC values were comparable to the reference cDTI\u2010derived mean diffusivity (MD) values (1.57\u2009\u00b1\u20090.05 vs. 1.56\u2009\u00b1\u20090.05\u2009\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      \/ms;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.404). Proposed relaxation maps received significantly lower quality scores than references, and diffusivity maps were comparable. Myocardial abnormalities in CA patients and MI swine were consistent with conventional methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The proposed method enables five\u2010slice, co\u2010registered, and free\u2010breathing myocardial T1, T2, and ADC maps in less than 5 min, facilitating integrated multi\u2010contrast tissue characterization in cardiac MRI. Future work will aim to optimize map quality and expand clinical applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70181","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T17:59:43Z","timestamp":1763229583000},"page":"2035-2051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Free\u2010Breathing Multi\u2010Slice Co\u2010Registered Cardiac\n                    <scp>T1<\/scp>\n                    ,\n                    <scp>T2<\/scp>\n                    , and\n                    <scp>ADC<\/scp>\n                    Mapping With Spin\u2010Echo Echo Planar Imaging"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-3231","authenticated-orcid":false,"given":"Dingheng","family":"Mai","sequence":"first","affiliation":[{"name":"Cardiovascular Innovation Research Center, Heart Vascular Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Biomedical Engineering Case Western Reserve University &amp; Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8369-798X","authenticated-orcid":false,"given":"Danielle","family":"Kara","sequence":"additional","affiliation":[{"name":"Cardiovascular Innovation Research Center, Heart Vascular Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"},{"name":"Department of Diagnostic Radiology Imaging Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3533-1697","authenticated-orcid":false,"given":"Yuchi","family":"Liu","sequence":"additional","affiliation":[{"name":"Cardiovascular MR R&amp;D Collaborations Siemens Medical Solutions USA, Inc.  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