{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:59:01Z","timestamp":1787792341748,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008982","name":"National Science Foundation of Sri Lanka","doi-asserted-by":"publisher","award":["2028829"],"award-info":[{"award-number":["2028829"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P51OD011092"],"award-info":[{"award-number":["P51OD011092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB032321"],"award-info":[{"award-number":["R01EB032321"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Electron paramagnetic resonance oxygen imaging (\n                      <jats:styled-content style=\"fixed-case\">EPROI<\/jats:styled-content>\n                      ) techniques have the ability to quantify the partial pressure of oxygen (\n                      <jats:styled-content style=\"fixed-case\">\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:styled-content>\n                      ), in vivo, through quantitative measurement of T\n                      <jats:sub>1e<\/jats:sub>\n                      maps of the trityl radical,\n                      <jats:styled-content style=\"fixed-case\">OXO71<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">OXO71<\/jats:styled-content>\n                      \u2010based\n                      <jats:styled-content style=\"fixed-case\">EPROI<\/jats:styled-content>\n                      has seen several applications in small animal imaging studies, but translation to humans will benefit from optimization of\n                      <jats:styled-content style=\"fixed-case\">EPROI<\/jats:styled-content>\n                      using large animal subjects that are anatomically and physiologically similar to humans. The goal of this study was to characterize pharmacokinetics and tissue distribution following an intravenous administration of\n                      <jats:styled-content style=\"fixed-case\">OXO71<\/jats:styled-content>\n                      in rhesus macaques.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 92\u2009\u03bcmol\/kg OXO71 dose, equivalent to doses used in studies with other animal species, was administered as a bolus injection over a 10\u2010min period in 3 animals. Plasma and urine were sampled over the subsequent 2\u2009h. A second equivalent dose was then rapidly administered, animals were euthanized, and OXO71 distribution was assessed in harvested tissues by EPR imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pharmacokinetics of plasma OXO71 determined by EPR spectroscopy showed biphasic clearance, characterized by distinct initial and terminal half\u2010lives of 12.4\u2009\u00b1\u20091.2 min and 67.7\u2009\u00b1\u20098.9\u2009min, respectively. Some variability in trityl concentration was observed between organs, but appreciable concentration was found for all tissues except the brain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>No adverse physiological effects of the infusions were observed, consistent with a low toxicity of OXO71. These findings indicate EPROI using OXO71 is safe in primates, and provide information related to the dose and time constraints for performing EPROI in other large animal species including humans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70214","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T06:55:31Z","timestamp":1765868131000},"page":"2459-2468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trityl\n                    <scp>OXO71<\/scp>\n                    Pharmacokinetics and Distribution in Rhesus Macaques"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-3632","authenticated-orcid":false,"given":"Christopher D.","family":"Kroenke","sequence":"first","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center Oregon Health &amp; Science University  Beaverton Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Canavesi","sequence":"additional","affiliation":[{"name":"Oxygen Measurement Core O2M Technologies, LLC  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna N.","family":"Castro","sequence":"additional","affiliation":[{"name":"Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center Oregon Health &amp; Science University  Beaverton Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Karpf","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center Oregon Health &amp; Science University  Beaverton Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raman","family":"Khurana","sequence":"additional","affiliation":[{"name":"Oxygen Measurement Core O2M Technologies, LLC  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Holloway","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences, School of Pharmacy West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitasha S.","family":"Palha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, School of Medicine University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Legenzov","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, School of Medicine University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan P.","family":"Crilly","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine, Oregon National Primate Research Center Oregon Health &amp; Science University  Beaverton Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-7029","authenticated-orcid":false,"given":"Boris","family":"Epel","sequence":"additional","affiliation":[{"name":"Oxygen Measurement Core O2M Technologies, LLC  Chicago Illinois USA"},{"name":"Department of Radiation and Cellular Oncology The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1402-413X","authenticated-orcid":false,"given":"Benoit","family":"Driesschaert","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences, School of Pharmacy West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4606-0239","authenticated-orcid":false,"given":"Viresh H.","family":"Rawal","sequence":"additional","affiliation":[{"name":"Department of Chemistry The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8875-2180","authenticated-orcid":false,"given":"Joseph P. Y.","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, School of Medicine University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Buehler","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pathology, Center for Blood Oxygen Transport and Hemostasis, School of Medicine University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1553-3702","authenticated-orcid":false,"given":"Victoria H. J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center Oregon Health &amp; Science University  Beaverton Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2264-0247","authenticated-orcid":false,"given":"Mrignayani","family":"Kotecha","sequence":"additional","affiliation":[{"name":"Oxygen Measurement Core O2M Technologies, LLC  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24926"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2017.04.017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-42099-w"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29811"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0620-8_15"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.10.041"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-023-01852-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29994"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-024-01963-5"},{"key":"e_1_2_8_11_1","article-title":"Low Field Magnetic Resonance Imaging to Detect Acute Kidney Injury","author":"Kishimoto S.","year":"2025","journal-title":"bioRxiv"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20714"},{"key":"e_1_2_8_13_1","volume-title":"Oxygen Imaging Instrument","author":"Kotecha M.","year":"2021"},{"key":"e_1_2_8_14_1","volume-title":"Animal Temperature Control System","author":"Epel B.","year":"2021"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo011068f"},{"key":"e_1_2_8_16_1","first-page":"35073","volume-title":"Synthesis of Hydroxyethyl Tetrathiatriarylmethyl Radicals OX063 and OX071","author":"Poncelet M.","year":"2019"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2AN01527G"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/b819259f"},{"key":"e_1_2_8_20_1","volume-title":"Animal Temperature Control Apparatus, System, and Methods Thereof","author":"Kotecha M.","year":"2022"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx9001379"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.30473"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20222"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.6b00277"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623319867053"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrm.70214","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:06:28Z","timestamp":1770908788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.70214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/mrm.70214"],"URL":"https:\/\/doi.org\/10.1002\/mrm.70214","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"assertion":[{"value":"2025-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}