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The processing pipeline included rigid motion correction and co\u2010registration of the CEST images with the 3D T\n                      <jats:sub>1w<\/jats:sub>\n                      images using Advanced Normalization Tools (ANTs). MTR\n                      <jats:sub>asym<\/jats:sub>\n                      maps at 1\u2009ppm, 2\u2009ppm and 3.5\u2009ppm were generated on a voxel\u2010by\u2010voxel basis. Each subject's 3D T1w images were processed with FreeSurfer to generate brain region specific ROIs, and the MTR\n                      <jats:sub>asym<\/jats:sub>\n                      values were averaged over the generated ROIs. In addition, a 6\u2010pool Lorentzian multi\u2010peak model was fitted to averaged Z\u2010spectrum data per ROI. Between\u2010group (CI vs. CN) CEST effects were evaluated using Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Motion correction reduced artifacts and visually improved CEST results. Multiple cortical and white matter ROIs showed differences in MTR\n                      <jats:sub>asym<\/jats:sub>\n                      values between CI and CN groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Overall, the mean MTR\n                      <jats:sub>asym<\/jats:sub>\n                      and Lorentzian amplitudes were lower in the CI than in the CN group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our proposed pipeline enables robust data analysis using either MTR\n                      <jats:sub>asym<\/jats:sub>\n                      or multi\u2010pool Lorentzian quantification approaches. The results suggest feasibility for detecting CEST differences between CI and CN groups in brain regions previously implicated in AD, motivating future validation in larger cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70240","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T03:45:02Z","timestamp":1767584702000},"page":"2828-2839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>CEST MRI<\/scp>\n                    Processing Pipeline in Pilot Study of Alzheimer's Disease Patients"],"prefix":"10.1002","volume":"95","author":[{"given":"Alexander","family":"Asturias","sequence":"first","affiliation":[{"name":"Department of Radiology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang Frank","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Advanced Imaging Research Center University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Davenport","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Advanced Imaging Research Center University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan J.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan E.","family":"Dimitrov","sequence":"additional","affiliation":[{"name":"Advanced Imaging Research Center University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Philips  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Keupp","sequence":"additional","affiliation":[{"name":"Philips Innovative Technologies  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4607-4147","authenticated-orcid":false,"given":"Elena","family":"Vinogradov","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Advanced Imaging Research Center University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.37765\/ajmc.2020.88482"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_9_4_1","volume-title":"FDA Grants Accelerated Approval for Alzheimer's Drug","author":"FDA","year":"2021"},{"key":"e_1_2_9_5_1","unstructured":"FDA \u201cFDA Converts Novel Alzheimer's Disease Treatment to Traditional Approval \u201d2023."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22761"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2012.11.024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85168-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/58\/22\/R221"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2021.101944"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4906"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020451"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3317"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.5160"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4AN00346B"},{"key":"e_1_2_9_16_1","volume-title":"Development of CEST MRI for the Characterization of Alzheimer's Disease","author":"Yu F. 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