{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:12:15Z","timestamp":1773029535329,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR079484"],"award-info":[{"award-number":["R01AR079484"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Purpose<\/jats:title>\n \n Ultrashort echo time (UTE) MRI enables direct imaging of cortical bone and quantification of its water compartments via bicomponent T\n 2<\/jats:sub>\n * modeling. However, conventional approaches require multiple separate dual\u2010echo scans due to limitations in gradient power. This approach is prone to inter\u2010scan inconsistencies such as motion and signal drift, which degrade fitting accuracy. This study proposes an interleaved dual\u2010echo acquisition sequence that acquires multiple echo time (TE) images in a single scan to improve bicomponent T\n 2<\/jats:sub>\n * quantification in cortical bone.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The proposed UTE sequence utilizes interleaved dual\u2010echo acquisitions with flexible TE spacings. This sequence was tested on five healthy subjects' tibial midshafts and compared to conventional separate dual\u2010echo scans with and without image registration. Bicomponent T\n 2<\/jats:sub>\n * modeling was performed, and fitting accuracy was evaluated using normalized\u2010root\u2010mean\u2010squared error (NRMSE). Three subjects were scanned three times to evaluate the scan repeatability.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The interleaved method significantly reduced NRMSE (3.2%\u2009\u00b1\u20092.3% vs. 6.2%\u2009\u00b1\u20093.1%,\n p<\/jats:italic>\n \u2009=\u20090.0231) and yielded lower and more stable T\n 2<\/jats:sub>\n * (T\n 2s<\/jats:sub>\n *; 0.50\u2009\u00b1\u20090.10\u2009ms vs. 0.76\u2009\u00b1\u20090.13\u2009ms,\n p<\/jats:italic>\n \u2009<\u20090.0001) and fraction (F\n s<\/jats:sub>\n ; 78.2\u2009\u00b1\u20095.1 vs. 84.2%\u2009\u00b1\u20097.1%,\n p<\/jats:italic>\n \u2009=\u20090.0006) of short T\n 2<\/jats:sub>\n components compared to separate scans without registration. Image registration had a minimal improvement on mapping results for separate scans. Parameter maps from the interleaved scans confirmed more homogeneous distributions of T\n 2s<\/jats:sub>\n * and F\n s<\/jats:sub>\n with lower fitting errors. The much lower coefficients of variance of the interleaved scans demonstrated improved repeatability compared with separate scans.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The proposed interleaved UTE dual\u2010echo sequence improves the robustness of bicomponent T\n 2<\/jats:sub>\n * mapping of the cortical bone by reducing inter\u2010scan inconsistencies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mrm.70245","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T03:46:01Z","timestamp":1767584761000},"page":"2755-2764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bicomponent Mapping of Cortical Bone Using a New Interleaved\n UTE<\/scp>\n Imaging Sequence"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1875-2908","authenticated-orcid":false,"given":"Soo Hyun","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Radiology University of California San Diego La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-1052","authenticated-orcid":false,"given":"Jiyo S.","family":"Athertya","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Diego La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arya","family":"Suprana","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Diego La Jolla California USA"},{"name":"Shu Chien\u2010Gene Lay Department of Bioengineering University of California San Diego La Jolla California 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