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We then developed two DWI protocols (\n                      <jats:italic>b<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      \u2009=\u20091000 and 3000\u2009s\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ) with minimized echo time (TE) and tested them on volunteers and patients. We validated apparent diffusion coefficient (ADC) maps from the nonlinear gradient acquisition against the reference (linear gradients only). We quantified improvements in signal\u2010to\u2010noise ratio (SNR), lesion contrast\u2010to\u2010noise ratio (CNR), and lesion\u2010to\u2010normal\u2010tissue contrast ratio in the compartmental map of restricted diffusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Corrections effectively reduced nonlinear\u2010gradient DWI artifacts. ADC maps from linear\u2010 and nonlinear\u2010gradient\u2010encoded studies agreed well, with a normalized root\u2010mean\u2010square\u2010error of \u223c10%, a common level of ADC variation. TE was significantly reduced from 57 to 42\u201347\u2009ms for moderate\n                      <jats:italic>b<\/jats:italic>\n                      \u2010values (\u2264\u20091000\u2009s\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ) and from 72 to 42\u201354\u2009ms for high\n                      <jats:italic>b<\/jats:italic>\n                      \u2010values (\u2264\u20093000\u2009s\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ). Consequently, SNR increased by 3%\u201338% (median 16%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and 7%\u201338% (median 26%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), respectively. Lesion CNR improved by a median of 133% at\n                      <jats:italic>b<\/jats:italic>\n                      \u2009=\u20092000\u2009s\/mm\n                      <jats:sup>2<\/jats:sup>\n                      and 217% at\n                      <jats:italic>b<\/jats:italic>\n                      \u2009=\u20093000\u2009s\/mm\n                      <jats:sup>2<\/jats:sup>\n                      . The restricted diffusion component in lesions was more conspicuous at short TE, with a median 23% increase in lesion\u2010to\u2010normal\u2010tissue contrast ratio (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The inside\u2010out nonlinear gradient coil enhances prostate DWI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70252","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:46:02Z","timestamp":1767894362000},"page":"2671-2688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Strong\u2010Gradient Diffusion\u2010Weighted Imaging of Prostate Cancer Using an Inside\u2010Out Nonlinear Gradient Coil"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1416-2380","authenticated-orcid":false,"given":"Horace Z.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahla M. 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