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Vetenskaps- och Vitterhets-Samh\u00e4llet i G\u00f6teborg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      The intravoxel incoherent motion (IVIM) model is commonly used to separate the effects of motion related to diffusion and blood microcirculation (perfusion) on the MR signal. Depending on the encoding time (\n                      <jats:italic>T<\/jats:italic>\n                      ), it is possible to probe the different temporal regimes of blood motion, which resemble a ballistic flow at short\n                      <jats:italic>T<\/jats:italic>\n                      and a pseudo\u2010diffusion at long\n                      <jats:italic>T<\/jats:italic>\n                      . The purpose of this work was to derive an encoding\u2010time\u2010dependent analytical model for flow\u2010compensated IVIM and to estimate the corresponding microvascular IVIM parameters in healthy brain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Theory and Methods<\/jats:title>\n                    <jats:p>\n                      An encoding\u2010time\u2010dependent analytical IVIM model was derived for flow\u2010compensated\/non\u2010flow\u2010compensated (FC\/NC) double diffusion encoding (DDE) from the Langevin equation and validated using simulations. Eleven healthy participants were scanned to estimate microvascular IVIM parameters (blood velocity \u03bd and blood correlation time \u03c4) in healthy brain using the proposed model, with\n                      <jats:italic>T<\/jats:italic>\n                      \u2009=\u200950\u2013100\u2009ms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The IVIM parameters were estimated to be\n                      <jats:italic>\u03c4<\/jats:italic>\n                      \u2009=\u2009123.1\u2009\u00b1\u200950\u2009ms,\n                      <jats:italic>\u03bd<\/jats:italic>\n                      \u2009=\u20091.51\u2009\u00b1\u20090.76\u2009mm\/s, perfusion fraction\n                      <jats:italic>f<\/jats:italic>\n                      \u2009=\u20094.75\u2009\u00b1\u20091.94%, and tissue diffusion coefficient\n                      <jats:italic>D\u2009=<\/jats:italic>\n                      \u20090.91\u2009\u00b1\u20090.32\u2009\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      \/ms in the healthy human brain, although simulations indicate a positive bias for\n                      <jats:italic>\u03c4<\/jats:italic>\n                      . For very short\/long\n                      <jats:italic>T<\/jats:italic>\n                      , the proposed model approaches established models for the ballistic\/diffusive regimes. Pseudocode for the derivation of the analytical model is presented to facilitate a transfer to other gradient waveforms or pulse sequences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An encoding\u2010time\u2010dependent analytical IVIM model is presented for FC\/NC DDE. In vivo results and simulations indicate that IVIM experiments with encoding times typical for clinical MRI scanners probe an intermediate to ballistic blood flow regime in the brain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70267","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:33:22Z","timestamp":1769495602000},"page":"3476-3487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modeling the Intermediate Flow Regime in Flow\u2010Compensated Intravoxel Incoherent Motion\n                    <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8937-023X","authenticated-orcid":false,"given":"Louise","family":"Rosenqvist","sequence":"first","affiliation":[{"name":"Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Montelius","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-3363","authenticated-orcid":false,"given":"Isabella M.","family":"Bj\u00f6rkman\u2010Burtscher","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Radiology Sahlgrenska University Hospital  Gothenburg, Region V\u00e4stra G\u00f6taland Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Petersson","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ljungberg","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Medical Physics and Biomedical Engineering Sahlgrenska University Hospital  Gothenburg, Region V\u00e4stra G\u00f6taland Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2741-5890","authenticated-orcid":false,"given":"Oscar","family":"Jalnefjord","sequence":"additional","affiliation":[{"name":"Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Medical Physics and Biomedical Engineering Sahlgrenska University Hospital  Gothenburg, Region V\u00e4stra G\u00f6taland Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.2.3393671"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.597170"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.596093"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25410"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27879"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3505"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25901"},{"key":"e_1_2_11_9_1","unstructured":"A. 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