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The numerical findings were then validated using the in vivo IVIM data from four healthy volunteers on a 3\u2010Tesla MRI scanner. Finally, a numerical framework for optimizing the T2\u2010IVIM protocol for relaxation\u2010compensated\n                      <jats:italic>f<\/jats:italic>\n                      parameter estimation was proposed and tested using the in vivo data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In vivo, the traditional IVIM model showed a trend toward higher\n                      <jats:italic>f<\/jats:italic>\n                      with increasing TE in the liver (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u20090.46,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023), but not in the kidney cortex (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u2009\u22120.067,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.76) or medulla (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u20090.039,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.86). In both simulations and in vivo, 2D T2\u2010IVIM modeling yielded lower\n                      <jats:italic>f<\/jats:italic>\n                      values and reduced variability in the liver. Our results further suggest that a\n                      <jats:italic>b<\/jats:italic>\n                      \u2010TE protocol with six\n                      <jats:italic>b<\/jats:italic>\n                      \u2010values and three TEs (50, 60, and 100\u2009ms) may be optimal for liver T2\u2010IVIM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The extended 2D T2\u2010IVIM model effectively minimizes the TE\u2010dependent bias in\n                      <jats:italic>f<\/jats:italic>\n                      and allows simultaneous estimation of the IVIM parameter and compartmental T2 values in abdominal organs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70278","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T06:24:21Z","timestamp":1770013461000},"page":"3161-3175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Toward Optimized Intravoxel Incoherent Motion (\n                    <scp>IVIM<\/scp>\n                    ) and Compartmental T2 Mapping in Abdominal Organs"],"prefix":"10.1002","volume":"95","author":[{"given":"Julia","family":"Stabinska","sequence":"first","affiliation":[{"name":"F.M. 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