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Contrast agent was injected in the middle of the scan. Dynamic images were reconstructed utilizing a linear tangent space alignment (LTSA) model. The pre\u2010 and postcontrast\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      * was estimated by finding the best fit between the measured signal and the MR signal model, which assumes a linearly time\u2010varying\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      * that accounts for\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      * changes after the contrast agent injection. Cardiac cine images were synthesized by fitting with the signal model. The 3D ECV mapping was performed using the 3D pre\u2010 and postcontrast\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      * maps and the measured hematocrit level from blood sampling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The feasibility of the proposed method was demonstrated through in vivo studies conducted on three healthy subjects using a 3T MR scanner. The ECV maps from the proposed method showed good agreement with those from the MOLLI method. The estimated average myocardial ECV from the proposed and MOLLI methods was 29.82%\u2009\u00b1\u20092.45% and 29.28%\u2009\u00b1\u20092.15%, respectively. The cine images from the proposed method successfully captured the heart's motion. The estimated ejection fraction was 63.3%\u2009\u00b1\u20098%, which was in good agreement with literature values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We developed a novel approach that allows 3D cardiac ECV mapping in a single, free\u2010running, continuous 15\u2010min scan with mid\u2010scan contrast injection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70293","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:35:32Z","timestamp":1770615332000},"page":"3360-3368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Free\u2010Running Three\u2010Dimensional Cardiac Extracellular Volume Mapping in a Single Scan With Mid\u2010Scan Contrast Injection"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2144-0211","authenticated-orcid":false,"given":"Wonil","family":"Lee","sequence":"first","affiliation":[{"name":"Yale Biomedical Imaging Institute Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Radiology and Biomedical Imaging Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-1347","authenticated-orcid":false,"given":"Paul Kyu","family":"Han","sequence":"additional","affiliation":[{"name":"Yale Biomedical Imaging Institute Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Radiology and Biomedical Imaging Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8669-1003","authenticated-orcid":false,"given":"Thibault","family":"Marin","sequence":"additional","affiliation":[{"name":"Yale Biomedical Imaging Institute Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Radiology and Biomedical Imaging Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Biomedical Informatics and Data Sciences Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8852-5359","authenticated-orcid":false,"given":"Isma\u00ebl B. 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