{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:11:30Z","timestamp":1778303490633,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07794"],"award-info":[{"award-number":["22K07794"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To develop and evaluate a motion\u2010compensated diffusion imaging with phase\u2010contrast (MC\u2010DIP) technique for mitigating errors in regional cerebral blood flow (rCBF) quantification caused by physiological brain motion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Diffusion\u2010weighted images were acquired in 11 healthy volunteers on a 3.0\u2009T MRI system using three gradient schemes: second\u2010order motion\u2010compensated (2nd\u2010MC), first\u2010order motion\u2010compensated (1st\u2010MC), and non\u2010compensated (non\u2010MC) diffusion gradients. Absolute rCBF maps were generated for each scheme by calibrating intravoxel incoherent motion\u2010derived relative perfusion maps with total cerebral blood flow measured by phase\u2010contrast MRI. The rCBF values from the DIP methods were compared in gray and white matter with a reference arterial spin labeling (ASL) measurement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both motion\u2010compensated schemes (2nd\u2010MC and 1st\u2010MC) provided significantly better biexponential fitting accuracy in gray matter compared with the non\u2010MC scheme (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In white matter, however, only the 2nd\u2010MC scheme resulted in a significant improvement over the other methods (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). While rCBF values from all three DIP methods showed a strong positive correlation with ASL in gray matter (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009\u2265\u20090.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), only the 2nd\u2010MC\u2010DIP method demonstrated a significant positive correlation in white matter (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The implementation of second\u2010order motion compensation within the DIP framework improves fitting accuracy, enabling robust rCBF quantification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70324","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:42:48Z","timestamp":1772966568000},"page":"238-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Motion\u2010Compensated Diffusion Imaging With Phase\u2010Contrast for Robust Quantification of Regional Cerebral Blood Flow"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7720-8040","authenticated-orcid":false,"given":"Naoki","family":"Ohno","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University  Kanazawa Japan"},{"name":"Graduate School of Medical Sciences, Kanazawa University  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tosiaki","family":"Miyati","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Sciences, Kanazawa University  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genki","family":"Nambu","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Fukui  Fukui Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7742-6259","authenticated-orcid":false,"given":"Yu","family":"Ueda","sequence":"additional","affiliation":[{"name":"Philips Japan  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Makino","sequence":"additional","affiliation":[{"name":"Radiology Division Kanazawa University Hospital  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noam","family":"Alperin","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Miami  Miami Florida 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