{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T05:12:53Z","timestamp":1778303573459,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81627901"],"award-info":[{"award-number":["81627901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To enable simultaneous free\u2010breathing imaging of the entire lung and heart with isotropic resolution at 1.5\u2009T for the diagnosis of cardiopulmonary disorders, while reducing scan time and minimizing the requirement for patient compliance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A three\u2010dimensional radial dual\u2010echo balanced steady\u2010state free precession (bSSFP) sequence was developed to acquire cardiopulmonary data in a free\u2010running fashion. All acquired data were binned into different respiratory and cardiac motion states according to respiratory and cardiac signals estimated from superior\u2013inferior navigators. A novel subspace\u2010based motion\u2013compensation reconstruction algorithm was used to reconstruct five\u2010dimensional (5D) cardiopulmonary images. Images acquired with the dual\u2010echo bSSFP sequence were compared with those acquired using an ultrashort echo time gradient\u2010echo (GRE\u2010UTE) sequence. The proposed 5D imaging technique was also compared with respiration\u2010resolved four\u2010dimensional (4D) imaging in 12 healthy subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The dual\u2010echo bSSFP sequence effectively captured pulmonary signals while providing superior myocardium\u2013blood contrast compared with the GRE\u2010UTE sequence. Dynamic images of the entire lungs and heart were simultaneously obtained using the proposed 5D imaging technique. By minimizing the adverse effect of cardiac motion, 5D imaging yielded clearer depiction of cardiac structures and pulmonary structures adjacent to the heart than 4D imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      A new simultaneous cardiopulmonary MRI technique was proposed in this study. Five\u2010dimensional dynamic images of the entire lungs and heart with an isotropic resolution of 1.5\u2009\u00d7\u20091.5\u2009\u00d7\u20091.5\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      can be obtained from a single free\u2010breathing scan of approximately 10\u2009min. This technique has the potential for structural and functional assessment of the cardiopulmonary system.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70334","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:31:19Z","timestamp":1773203479000},"page":"161-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Free\u2010Running Simultaneous Imaging of the Entire Lung and Heart With Isotropic Resolution"],"prefix":"10.1002","volume":"96","author":[{"given":"Zekang","family":"Ding","sequence":"first","affiliation":[{"name":"National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, Shanghai Jiao Tong University  Shanghai 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