{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:39:31Z","timestamp":1787063971760,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/S021930\/1"],"award-info":[{"award-number":["EP\/S021930\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To characterize the diffusion properties of prostate epithelium and stroma in benign tissue and cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Paired MR microscopy (20\u2009\u03bcm) and multidimensional diffusion MRI (dMRI) (160\u2009\u03bcm,\n                      <jats:italic>b<\/jats:italic>\n                      \u2009=\u20091000\u20132000\u2009s\/mm\n                      <jats:sup>2<\/jats:sup>\n                      , \u2206\u2009=\u200915\u2013120\u2009ms) were performed at 16.4\u2009T on 17 fixed prostate tissue samples (14\u00d7 benign, 2\u00d7 Gleason 3\u2009+\u20093, 1\u00d7 Gleason 4\u2009+\u20094). MR microscopy images were used to segment epithelial, stromal, and luminal components in each sample. For each dMRI sequence, aggregate epithelial and stromal signal contributions in benign tissue were estimated using a linear epithelium\u2010stroma\u2010lumen signal model. Four diffusion signal models were fit to these aggregate signals. Quality\u2010of\u2010fit was assessed using the small\u2010sample corrected Akaike Information Criterion (AICc). Voxel\u2010wise model fitting was also performed to compare parameter estimates in benign tissue and cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Aggregate dMRI signal estimates for both epithelium and stroma were best described by the Ball\u2009+\u2009Sphere model (lowest AICc). A higher sphere fraction (0.278 vs. 0.175) and lower ball\u2010compartment diffusivity (0.611 vs. 0.943\u2009\u03bcm\n                      <jats:sup>2<\/jats:sup>\n                      \/ms) were estimated for epithelium compared to stroma. The ADC model provided the worst fit in both cases (highest AICc). For Gleason 3\u2009+\u20093 cancer, ADC and Ball\u2009+\u2009Sphere parameter estimates were consistent with the values found for benign epithelium and stroma; however, raised sphere fraction estimates were seen in Gleason 4\u2009+\u20094 cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Direction\u2010averaged diffusion in fixed prostate epithelium and stroma is well described by the Ball\u2009+\u2009Sphere model. The diffusion properties of epithelium in Gleason 3\u2009+\u20093 cancer and benign tissue appear to be similar; however, a marked increase to the volume fraction of restricted water was found for Gleason 4\u2009+\u20094 epithelium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70344","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T04:17:23Z","timestamp":1774412243000},"page":"349-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterizing the Diffusion Properties of Prostate Tissue Using Paired\n                    <scp>MR<\/scp>\n                    Microscopy and Multidimensional Diffusion\n                    <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8011-6139","authenticated-orcid":false,"given":"Adam","family":"Phipps","sequence":"first","affiliation":[{"name":"Centre for Medical 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