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The imaging parameters of WEFAST were optimized for maximizing spatial and temporal SNR. Its reproducibility and evaluation against the established WEPCAST technique were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Optimal scan parameters were determined to be velocity cut\u2010off\u2009=\u20092\u2009cm\/s and FTVS flip angle\u2009=\u200990\u00b0, and the spatial SNR reached 10.42\u2009\u00b1\u20091.30 which is significantly higher than that of other imaging protocols (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The scan time of WEFAST was significantly reduced (WEFAST vs. WEPCAST: 3\u2009min 50\u2009s vs. 6\u2009min 54\u2009s). The WEFAST sequence preserved robust reproducibility (intrasession CoV: extraction fraction (\n                      <jats:italic>E<\/jats:italic>\n                      )\u2009=\u20093.11%\u2009\u00b1\u20090.67%, permeability surface area product (PS)\u2009=\u200911.08%\u2009\u00b1\u20091.29%; intersession CoV:\n                      <jats:italic>E<\/jats:italic>\n                      \u2009=\u20093.17%\u2009\u00b1\u20090.76%, PS\u2009=\u200912.33%\u2009\u00b1\u20092.04%) and achieved good agreement with the WEPCAST in quantitative measurements (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u20090.59,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for\n                      <jats:italic>E<\/jats:italic>\n                      ;\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u20090.74,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for PS). Multidelay experiments further confirmed reliable quantification of venous water extraction signals in multiple venous structures such as the transverse sinus and straight sinus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proposed WEFAST sequence achieved significant acceleration in noncontrast BBB MR imaging by providing rapid and reliable quantification of BBB water permeability, with the potential for clinical applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70349","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T04:10:42Z","timestamp":1774411842000},"page":"568-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Noncontrast\n                    <scp>MR<\/scp>\n                    Imaging of Blood\u2013Brain Barrier Permeability: Halving Scan Time With Velocity\u2010Selective Preparation for Vessel Isolation"],"prefix":"10.1002","volume":"96","author":[{"given":"Yizhe","family":"Hu","sequence":"first","affiliation":[{"name":"Key Laboratory for Biomedical Engineering of the Ministry of Education, Department of Biomedical Engineering College of Biomedical Engineering &amp; Instrument Science, Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Cheng","family":"Hsu","sequence":"additional","affiliation":[{"name":"MR Collaboration, Siemens Healthineers Ltd.  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