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We systematically compared continuous\u2010wave (CW), hyperbolic\u2010secant 4 (HS4), and tan\u2013tanh (TAN) preparations ex vivo, and evaluated the feasibility and repeatability of UTE\u2010Ad\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>\n                        1\n                        <jats:italic>\u03c1<\/jats:italic>\n                      <\/jats:sub>\n                      mapping of the knee in vivo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      UTE\u2010Ad\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>\n                        1\n                        <jats:italic>\u03c1<\/jats:italic>\n                      <\/jats:sub>\n                      imaging was performed at 3\u2009T. A bovine tendon was imaged at 0\u00b0, 55\u00b0, and 90\u00b0 using CW, HS4 (3\/6\u2009ms), and TAN (3\/6\u2009ms) preparations at spin\u2010lock amplitudes of 500\u20131000\u2009Hz. Five healthy volunteers and five patients with knee osteoarthritis were scanned. Data were fit with mono\u2010exponential (ME) and stretched\u2010exponential (SE) models. Intrasubject repeatability was assessed in healthy volunteers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All preparations exhibited strong MAE (anisotropy ratios &gt;\u200940%). TAN pulses consistently produced lower\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>\n                        1\n                        <jats:italic>\u03c1<\/jats:italic>\n                      <\/jats:sub>\n                      values than HS4, indicating reduced\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      contamination (ex vivo). ME\u2010\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>\n                        1\n                        <jats:italic>\u03c1<\/jats:italic>\n                      <\/jats:sub>\n                      remained orientation\u2010dependent across all pulses, whereas the SE parameter \u03b1 was largely orientation\u2010independent (anisotropy ratio \u22482%\u201320%). TAN\u20106\u2009ms yielded\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>\n                        1\n                        <jats:italic>\u03c1<\/jats:italic>\n                      <\/jats:sub>\n                      values most consistent with CW, while HS4\u20106\u2009ms produced substantially higher values in the knee joint. TAN\u20106\u2009ms (CV\u2009=\u20093.47%) and HS4\u20106\u2009ms (CV\u2009=\u20094.24%) demonstrated better repeatability than CW (CV\u2009=\u20097.24%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Adiabatic pulse shape strongly influences\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      contamination, but none of the tested preparations eliminated MAE. TAN\u20106\u2009ms offered the best balance of reduced\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      contamination and high repeatability. The near orientation\u2010independence of the SE parameter \u03b1 suggests that it may serve as a more robust biomarker for highly ordered tissues.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70359","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:41:34Z","timestamp":1774500094000},"page":"611-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adiabatic Pulse Shape Influence on the Orientation Dependence of\n                    <i>T<\/i>\n                    <sub>\n                      1\n                      <i>\u03c1<\/i>\n                    <\/sub>\n                    Relaxation"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6620-9814","authenticated-orcid":false,"given":"Hector","family":"L. de Moura","sequence":"first","affiliation":[{"name":"Department of Radiology New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7841-9333","authenticated-orcid":false,"given":"Mahesh B.","family":"Keerthivasan","sequence":"additional","affiliation":[{"name":"Siemens Medical Solutions USA Inc  Malvern Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1513-770X","authenticated-orcid":false,"given":"Jonathan","family":"Samuels","sequence":"additional","affiliation":[{"name":"Department of Medicine New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-3625","authenticated-orcid":false,"given":"Marcelo V. 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