{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:51:59Z","timestamp":1781581919360,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 EB027061"],"award-info":[{"award-number":["P41 EB027061"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB029985"],"award-info":[{"award-number":["R01 EB029985"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Large FOV turbo\u2010spin\u2010echo (TSE) imaging at ultra\u2010high field (UHF) remains challenging due to B\n                      <jats:sub>1<\/jats:sub>\n                      <jats:sup>+<\/jats:sup>\n                      inhomogeneity and peak specific absorption rate (pSAR) limitations. This work presents a new time\u2010interleaved acquisition of modes (TIAMO) framework called SCOPE (Signal and Contrast Optimization with Predicted Excitations), which overcomes these challenges by enabling reduced repetition time (TR) without compromising image quality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TIAMO is implemented to operate at half the TR of standard static\u2010shim acquisitions, maintaining scan time parity with traditional acquisitions. To mitigate the expected contrast and signal loss from TR reduction, we developed a novel optimization framework that finds spatially exclusive RF modes, ensuring each voxel is predominantly excited by a single mode, thereby restoring the effective TR. To find these modes, the optimization utilizes an extended phase graph (EPG) model formulated to simulate the TSE signal with interleaved RF excitations. This new signal model is incorporated into the SCOPE framework to compute subject\u2010specific optimal shims. Previous TIAMO methods are reformulated using this new signal model to elucidate performance differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SCOPE produced more homogeneous images with improved pSAR efficiency by alternating SAR hotspots between modes. In vivo measurements in the prostate and kidneys strongly correlated to signal prediction and demonstrated superior image quality compared to prior TIAMO methods. The new signal model clarified performance tradeoffs between TIAMO strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SCOPE enables rapid, contrast\u2010preserving TSE TIAMO imaging with reduced TR, addressing the longstanding scan\u2010time penalty of TIAMO. This work establishes a foundation for real\u2010time, model\u2010driven pTx optimization in large\u2010FOV UHF imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70362","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:45:19Z","timestamp":1774583119000},"page":"635-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Signal and Contrast Optimization With Predicted Excitations (\n                    <scp>SCOPE<\/scp>\n                    ) for Accelerating Large\n                    <scp>FOV<\/scp>\n                    Body Imaging at\n                    <scp>UHF<\/scp>"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1679-7417","authenticated-orcid":false,"given":"Tobey D.","family":"Haluptzok","sequence":"first","affiliation":[{"name":"Center for Magnetic Resonance Research (CMRR) University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1835-4002","authenticated-orcid":false,"given":"Simon","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research (CMRR) University of Minnesota  Minneapolis Minnesota USA"},{"name":"Medical Physics in Radiology German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-6529","authenticated-orcid":false,"given":"Gregory J.","family":"Metzger","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research (CMRR) University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0B013E318234E75B"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000436"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.26498"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NICL.2012.09.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.26742"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/JMRI.24573"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.20978"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.25192"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3978\/J.ISSN.2223\u20104292.2014.02.06"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.24237"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.21476"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.23081"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0000000000000204"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/NBM.3313"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.22527"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.29318"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20102364(88)90128\u2010X"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.24153"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/JMRI.24619"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.10171"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.22927"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.30235"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.28739"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.30498"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.21120"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.26153"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/NBM.3195"},{"key":"e_1_2_8_29_1","first-page":"367","volume-title":"Proceedings of the 17th International Society for Magnetic Resonance in Medicine, Honolulu, Hawai'i, USA","author":"Van De Moortele P. F.","year":"2009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.22423"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.596828"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2006.871418"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.30032"},{"key":"e_1_2_8_34_1","unstructured":"R.Ye L.Chen W. B.Kou J.Zhang andH.Ishibuchi \u201cPareto Front Shape\u2010Agnostic Pareto Set Learning in Multi\u2010Objective Optimization \u201d2024 accessed July 27 2025 https:\/\/arxiv.org\/pdf\/2408.05778v1."},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.24935"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.21739"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.22978"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.23118"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.27149"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.29569"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.27645"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.25404"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.24751"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.28880"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/MRM.30201"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrm.70362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:00:56Z","timestamp":1781578856000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.70362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/mrm.70362"],"URL":"https:\/\/doi.org\/10.1002\/mrm.70362","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]},"assertion":[{"value":"2025-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}