{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:39:33Z","timestamp":1783021173683,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005357","name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","doi-asserted-by":"publisher","award":["21\u20100299"],"award-info":[{"award-number":["21\u20100299"]}],"id":[{"id":"10.13039\/501100005357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["221805\/Z\/20\/Z"],"award-info":[{"award-number":["221805\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/SCRF\/22\/32014"],"award-info":[{"award-number":["FS\/SCRF\/22\/32014"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/19\/18\/34252"],"award-info":[{"award-number":["FS\/19\/18\/34252"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Quantification of the creatine kinase (CK) forward reaction rate (\n                      <jats:italic>k<\/jats:italic>\n                      <jats:sub>f<\/jats:sub>\n                      ) in the human heart using phosphorus magnetic resonance spectroscopy is clinically important; however, it is limited by long acquisition times, operator subjectivity in analysis, and potential skeletal muscle contamination. This study evaluates if combining compartment\u2010based reconstruction techniques with acquisition\u2010weighted (AW) Triple Repetition Time Saturation Transfer (TRiST) acquisitions could overcome these challenges.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Healthy volunteers were scanned with a fully weighted (FW) TRiST protocol twice, and once with an AW TRiST protocol on a 3T MRI. The resulting spectra were reconstructed with conventional Fourier Transform (FT), as well as compartment\u2010based reconstruction techniques: Spectroscopy with Linear Algebra Modeling (SLAM), Spectral Localization by IMaging (SLIM), and an unweighted mean of the FT spectra (ROI\u2010FT).\n                      <jats:italic>k<\/jats:italic>\n                      <jats:sub>f<\/jats:sub>\n                      values were calculated and compared across reconstruction methods and acquisition types.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cardiac\n                      <jats:italic>k<\/jats:italic>\n                      <jats:sub>f<\/jats:sub>\n                      values from FW TRiST were 0.21\u2009\u00b1\u20090.07\u2009s\n                      <jats:sup>\u22121<\/jats:sup>\n                      (FT), 0.26\u2009\u00b1\u20090.08\u2009s\n                      <jats:sup>\u22121<\/jats:sup>\n                      (SLAM), 0.26\u2009\u00b1\u20090.07\u2009s\n                      <jats:sup>\u22121<\/jats:sup>\n                      (SLIM), and 0.30\u2009\u00b1\u20090.10s\n                      <jats:sup>\u22121<\/jats:sup>\n                      (ROI\u2010FT). Corresponding values from AW TRiST were 0.27\u2009\u00b1\u20090.07\u2009s\n                      <jats:sup>\u22121<\/jats:sup>\n                      , 0.25\u2009\u00b1\u20090.05\u2009s\n                      <jats:sup>\u22121<\/jats:sup>\n                      , 0.25\u2009\u00b1\u20090.04\u2009s\n                      <jats:sup>\u22121<\/jats:sup>\n                      , and 0.24\u2009\u00b1\u20090.08\u2009s\n                      <jats:sup>\u22121<\/jats:sup>\n                      , respectively. No significant differences were observed between FW and AW results. A significant decrease in cardiac PCr\/ATP ratios was observed for SLAM and SLIM reconstructed data, suggesting decreased signal contamination from skeletal muscle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Compartment\u2010based reconstruction techniques minimize the operator subjectivity present in the current FT method of analyzing TRiST experiments, in addition to reducing skeletal muscle contamination. When combined with an AW acquisition, scan times were reduced by 47% without compromising\n                      <jats:italic>k<\/jats:italic>\n                      <jats:sub>f<\/jats:sub>\n                      accuracy. This method provides a more robust and efficient evaluation of in vivo cardiac metabolism.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70408","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:01:57Z","timestamp":1777262517000},"page":"1066-1075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Faster and More Robust\n                    <scp>CK<\/scp>\n                    Reaction Rate Estimation at\n                    <scp>3T<\/scp>\n                    Using Acquisition\u2010Weighted\n                    <scp>\n                      <sup>31<\/sup>\n                      P\n                    <\/scp>\n                    Cardiac\n                    <scp>1D<\/scp>\n                    \u2010\n                    <scp>MRSI<\/scp>\n                    With Compartment\u2010Based Reconstruction"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5954-8977","authenticated-orcid":false,"given":"Aaron","family":"Axford","sequence":"first","affiliation":[{"name":"Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iveta","family":"Pajanov\u00e1","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine University of Oxford  Oxford UK"},{"name":"Department of Imaging Methods Institute of Measurement Science, Slovak Academy of Sciences  Bratislava Slovakia"},{"name":"Institute of Electrical Engineering, Faculty of Electrical Engineering and Information Technology, Slovak University of Technology  Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Watson","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine University of Oxford  Oxford UK"},{"name":"Department of Cardiovascular Medicine University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Tyler","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine University of Oxford  Oxford UK"},{"name":"Division of Psychology Communication and Human Neuroscience, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Xavier","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1361-4349","authenticated-orcid":false,"given":"Ferenc E.","family":"M\u00f3zes","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver J.","family":"Rider","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian J.","family":"Tyler","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine University of Oxford  Oxford UK"},{"name":"Department of Physiology, Anatomy &amp; Genetics University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-3642","authenticated-orcid":false,"given":"Ladislav","family":"Valkovi\u010d","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine University of Oxford  Oxford UK"},{"name":"Department of Imaging Methods Institute of Measurement Science, Slovak Academy of Sciences  Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02160-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007328"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7714"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063052"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1734121"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10130"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-015-0175-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22347"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00437a054"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4085"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043450"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2012.03.008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910080308"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1325458"},{"key":"e_1_2_8_16_1","volume-title":"Proceedings of the 28th Annual Meeting of ISMRM","author":"Zhou T.","year":"2020"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24142"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4950"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1997.1244"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185356"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408962102"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.613646"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.823187"},{"issue":"1","key":"e_1_2_8_24_1","first-page":"143","article-title":"Measuring PCr\/ATP as a Marker of Myocardial Energetics Across the Spectrum of Metabolic Cardiac Disease","volume":"24","author":"Henry J. 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