{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:39:35Z","timestamp":1783021175786,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF1204801"],"award-info":[{"award-number":["2023YFF1204801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["YDZX20243100003001001"],"award-info":[{"award-number":["YDZX20243100003001001"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      In vivo quantification of brain glutathione (GSH) is severely confounded by extreme spectral overlap in conventional\n                      <jats:sup>1<\/jats:sup>\n                      H MRS. We developed a novel StepWIse FilTering Point\u2010Resolved Spectroscopy (SWIFT\u2010PRESS) sequence to fundamentally address this inherent limitation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Transposing the stepwise filtering strategy from classical signal processing into quantum spin dynamics, SWIFT\u2010PRESS concatenates multiple customized filter modules. This cascaded architecture circumvents the inherent inability of single\u2010pass filters to simultaneously preserve target signals and completely eradicate interference. The proposed sequence was rigorously benchmarked against conventional PRESS and MEGA\u2010PRESS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Simulations and phantom validations demonstrated that SWIFT\u2010PRESS successfully eradicated the dominant creatine\u2010derived interference while maintaining a highly acceptable GSH retention yield of \u02dc70%. In vivo human brain acquisitions confirmed its exceptional selectivity and robustness in both the parietal lobe and the magnetically complex basal ganglia, yielding precise mean GSH concentrations of 2.45\u2009mM and 2.88\u2009mM, respectively. Crucially, SWIFT\u2010PRESS uncovered a pronounced inhomogeneous GSH distribution within the basal ganglia, directly reflecting underlying micro\u2010regional metabolic heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transcending the limitations of conventional spectral editing, SWIFT\u2010PRESS enables the highly specific, stable, and quantitative in vivo detection of brain GSH. By illuminating previously obscured spatial metabolic nuances, this technique establishes a robust methodological foundation for advanced clinical investigations of oxidative stress\u2010related disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70410","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:46:57Z","timestamp":1778644017000},"page":"1042-1053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A\n                    <scp>3T MRS<\/scp>\n                    Sequence for Quantification of Glutathione in Human Brain Using Stepwise Filtering"],"prefix":"10.1002","volume":"96","author":[{"given":"Xue","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Magnetic Resonance and Molecular Imaging in Medicine East China Normal University  Shanghai China"},{"name":"Physics Department &amp; Shanghai Key Laboratory of Magnetic Resonance School of Physics, East China Normal University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da\u2010Xiu","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Magnetic Resonance and Molecular Imaging in Medicine East China Normal University  Shanghai China"},{"name":"Physics Department &amp; Shanghai Key Laboratory of Magnetic Resonance School of Physics, East China Normal University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Magnetic Resonance and Molecular Imaging in Medicine East China Normal University  Shanghai China"},{"name":"Physics Department &amp; Shanghai Key Laboratory of Magnetic Resonance School of Physics, East China Normal University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaiying","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Magnetic Resonance and Molecular Imaging in Medicine East China Normal University  Shanghai China"},{"name":"Physics Department &amp; Shanghai Key Laboratory of Magnetic Resonance School of Physics, East China Normal University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Fu","sequence":"additional","affiliation":[{"name":"Application Developments Siemens Shenzhen Magnetic Resonance Ltd  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-2048","authenticated-orcid":false,"given":"Ye\u2010Feng","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute of Magnetic Resonance and Molecular Imaging in Medicine East China Normal University  Shanghai China"},{"name":"Physics Department &amp; Shanghai Key Laboratory of Magnetic Resonance School of Physics, East China Normal University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad356"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2004.02.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101263"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00486"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010025\u201001116\u20104"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091407"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360305"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.04.005"},{"key":"e_1_2_9_10_1","volume-title":"Proceedings of the 23rd Annual Meeting of International Society for Magnetic Resonance in Medicine","author":"Sailasuta N.","year":"2015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.09.017"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4826\u201014.2015"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27742"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4393"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26532"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099\u20101492(200005)13:3<129::aid\u2010nbm619>3.0.co;2\u2010v"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20788"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2009.02.002"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.70295"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26122"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21086"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29061"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910390420"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10208"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26619"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2019.10.004"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21832"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1994.1048"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10499"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29562"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28853"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2022.107188"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29824"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2009.06.008"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2522081399"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00168"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrm.70410","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:35:46Z","timestamp":1783017346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.70410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/mrm.70410"],"URL":"https:\/\/doi.org\/10.1002\/mrm.70410","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]},"assertion":[{"value":"2025-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}