{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:37:53Z","timestamp":1783021073185,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB031954"],"award-info":[{"award-number":["R01EB031954"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To investigate the utility of a recently demonstrated diffusion MRI derived axon diameter surrogate measure (\u2206\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>\u27c2<\/jats:sub>\n                      ) under pathologic conditions induced by a spinal cord injury model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Contusion injuries were performed on the thoracic\u2013lumbar spinal cord of adult male rats. Eight weeks post\u2010injury, rats were sacrificed and their spinal cords imaged by MRI and then scanning electron microscopy (SEM). Relationships between the difference in radial diffusivity with diffusion time (\u2206\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>\u27c2<\/jats:sub>\n                      ) as well as longitudinal relaxometry based metrics and effective axon diameter from SEM were evaluated across regions of interest in slices 2\u20135\u2009mm away from the injury epicenter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      \u2206\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>\u27c2<\/jats:sub>\n                      correlated strongly with histology derived effective axon diameter, while bound pool fraction and\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      of the free proton pool (\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>1f<\/jats:sub>\n                      ) had no significant correlations with effective axon diameter. A significant relationship was found between\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>1f<\/jats:sub>\n                      and \u2206\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>\u27c2<\/jats:sub>\n                      across slices.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In the context of contusion injured rat spinal cords, \u2206\n                      <jats:italic>D<\/jats:italic>\n                      <jats:sub>\u27c2<\/jats:sub>\n                      serves as a robust surrogate for axon diameter and provides complementary information to longitudinal relaxometry derived metrics.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70415","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T03:27:13Z","timestamp":1778470033000},"page":"1355-1364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Influence of Injury\u2010Induced Microstructural Variations on the Efficacy of a Diffusion\n                    <scp>MRI<\/scp>\n                    \u2010Derived Axon Diameter Surrogate"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0408-4831","authenticated-orcid":false,"given":"Hannah E.","family":"Alderson","sequence":"first","affiliation":[{"name":"Vanderbilt University Department of Biomedical Engineering  Nashville Tennessee USA"},{"name":"Vanderbilt University Institute of Imaging Science  Nashville Tennessee 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