{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:37:39Z","timestamp":1783021059891,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41EB015908"],"award-info":[{"award-number":["P41EB015908"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["S10OD018468"],"award-info":[{"award-number":["S10OD018468"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL170039"],"award-info":[{"award-number":["R01HL170039"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["MDA963281"],"award-info":[{"award-number":["MDA963281"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To deconvolve cardiac phase and hemodynamic effects in hyperpolarized (HP) [1\u2010\n                      <jats:sup>13<\/jats:sup>\n                      C]pyruvate and to develop a cardiac phase\u2010adjustable reconstruction framework.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Cardiac phase drift during dynamic acquisition of HP\n                      <jats:sup>13<\/jats:sup>\n                      C MRS and its effect on dynamic signal fidelity were simulated using a digital cardiac phantom. A hemodynamic model describing ventricular passages of HP pyruvate was developed and applied to dynamic cardiac\n                      <jats:sup>13<\/jats:sup>\n                      C MRS datasets acquired from healthy volunteers. Timecourses of HP pyruvate from multiphase\n                      <jats:sup>13<\/jats:sup>\n                      C MRI and\n                      <jats:sup>13<\/jats:sup>\n                      C MRS were fit to the hemodynamic model and were compared with multiphase\n                      <jats:sup>1<\/jats:sup>\n                      H and ECG timing. Phase\u2010adjustable reconstruction was demonstrated for ECG\u2010gated and nongated HP\n                      <jats:sup>13<\/jats:sup>\n                      C MRS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Phantom simulations demonstrated that heart rate variability induces cardiac phase misalignment, causing substantial distortion of dynamic HP pyruvate timecourses. Human studies showed transient heart rate changes during pyruvate bolus arrival, resulting in phase shifts. Multiphase\n                      <jats:sup>13<\/jats:sup>\n                      C MRI confirmed that pyruvate signal is correlated with ventricular volume (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009=\u20090.88\u2009\u00b1\u20090.08), with diastolic signals exceeding systolic signals in both ventricles and LV peak less than half of RV. The hemodynamic model accurately depicted in vivo cardiac\n                      <jats:sup>13<\/jats:sup>\n                      C MRS (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      \u2009&gt;\u20090.978), separating LV, RV, and recirculation components and estimating pulmonary transit times consistent with image\u2010based measurements. Retrospective phase correction enabled reconstruction of dynamic HP pyruvate timecourses aligned to specific cardiac phases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We present a volume\u2010guided hemodynamic modeling and reconstruction framework that corrects cardiac phase misalignment. This approach improves quantitative robustness across varying heart rates and is applicable to both ECG\u2010gated and nongated acquisitions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70426","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T03:22:21Z","timestamp":1778469741000},"page":"1054-1065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemodynamic Modeling and Phase\u2010Adjustable Reconstruction of Hyperpolarized Cardiac\n                    <scp>\n                      <sup>13<\/sup>\n                      C MRS\n                    <\/scp>\n                    Using\n                    <scp>\n                      <sup>1<\/sup>\n                      H\n                    <\/scp>\n                    Cine and\n                    <scp>ECG<\/scp>\n                    Timing"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1384-4037","authenticated-orcid":false,"given":"Sung\u2010Han","family":"Lin","sequence":"first","affiliation":[{"name":"Advanced Imaging Research Center UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Mozingo","sequence":"additional","affiliation":[{"name":"Advanced Imaging Research Center UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal E.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Advanced Imaging Research Center UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley A.","family":"Derner","sequence":"additional","affiliation":[{"name":"Advanced Imaging Research Center UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5077-0642","authenticated-orcid":false,"given":"Craig R.","family":"Malloy","sequence":"additional","affiliation":[{"name":"Advanced Imaging Research Center UT Southwestern Medical Center  Dallas Texas USA"},{"name":"VA North Texas Healthcare System  Dallas Texas USA"},{"name":"Department of Radiology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-6971","authenticated-orcid":false,"given":"Jae Mo","family":"Park","sequence":"additional","affiliation":[{"name":"Advanced Imaging Research Center UT Southwestern Medical Center  Dallas Texas USA"},{"name":"Department of Radiology UT Southwestern Medical Center  Dallas Texas USA"},{"name":"Department of Biomedical Engineering UT Southwestern Medical Center  Dallas Texas USA"},{"name":"Charles and Jane Pak Center for Mineral Metabolism and Clinical Research UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601319103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21460"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309769"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00607-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.08.017"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-1195"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316260"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocmr.2024.101095"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jez074"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.782745"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.317970"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29042"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-014-0063-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006070"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69747-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0355-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jead001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28796"},{"key":"e_1_2_9_20_1","unstructured":"J. R.Alger J. M.Park J.Ma et al. \u201cPyruvate Infusion Rates for Hyperpolarized Metabolite Imaging of Human Heart \u201d2021."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21292"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2006.07.013"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrm.70426","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:38:07Z","timestamp":1783017487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.70426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,10]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/mrm.70426"],"URL":"https:\/\/doi.org\/10.1002\/mrm.70426","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,10]]},"assertion":[{"value":"2025-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}