{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:01:47Z","timestamp":1785445307628,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF1204801"],"award-info":[{"award-number":["2023YFF1204801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302156"],"award-info":[{"award-number":["82302156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1403900"],"award-info":[{"award-number":["22ZR1403900"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Intracranial angiography and susceptibility imaging are two important modalities for assessment of cerebral disorders. This study aims to develop a simultaneous intracranial angiography and susceptibility imaging (SIAS) sequence with high acquisition efficiency and good visibility of distal cerebral vessels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SIAS embeds multi\u2010echo susceptibility\u2010weighted imaging (SWI) within the velocity\u2010selective arterial spin labeling (VSASL) MRA. Sequence parameters, including lines per shot (LPS) and SWI flip angle (FA), were optimized in healthy volunteers. Mutual influence between VSASL and SWI acquisition was also evaluated. SIAS was then compared with conventional VSASL, TOF, and SWI. Quantitative metrics included arterial length, sharpness and intensity; vein sharpness; and susceptibility values. Artery\u2013vein separation in SIAS\u2010VSASL was performed using a susceptibility\u2010guided strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lower LPS improved distal vessel depiction but reduced carotid siphon visibility in both conventional VSASL and SIAS\u2010VSASL. A centric\u2010in SWI readout enhanced vein sharpness and yielded better visualization of proximal arteries. Increasing SWI FA also improved vein sharpness but reduced vessel length. SIAS\u2010VSASL visualized distal artery better than TOF, and improved proximal artery sharpness over VSASL. SIAS\u2010SWI yielded sharper vein depiction and reliable susceptibility quantification. The proposed susceptibility\u2010guided post\u2010processing enabled effective artery\u2013vein separation in SIAS\u2010VSASL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SIAS provides good visualization of small arteries while supporting hemorrhage detection, quantitative susceptibility mapping reconstruction, and venous imaging, which facilitate artery\u2013vein separation in SIAS\u2010VSASL. It demonstrates strong potential for comprehensive assessment of brain disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70441","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T04:26:47Z","timestamp":1779683207000},"page":"1589-1604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous Intracranial Angiography and Susceptibility Imaging (\n                    <scp>SIAS<\/scp>\n                    ) by Combining Velocity\u2010Selective\n                    <scp>ASL<\/scp>\n                    and Multi\u2010Echo\n                    <scp>SWI<\/scp>"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7885-4443","authenticated-orcid":false,"given":"Lixin","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence Fudan University  Shanghai 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Ministry of Education  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence Fudan University  Shanghai China"},{"name":"Key Laboratory of Computational Neuroscience and Brain\u2010Inspired Intelligence (Fudan University) Ministry of Education  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7975-2528","authenticated-orcid":false,"given":"Zhensen","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence Fudan University  Shanghai China"},{"name":"Key Laboratory of Computational Neuroscience and Brain\u2010Inspired Intelligence (Fudan University) Ministry of Education  Shanghai 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