{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:29:57Z","timestamp":1788470997943,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA269234"],"award-info":[{"award-number":["R01 CA269234"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB004031"],"award-info":[{"award-number":["R01 EB004031"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB036124"],"award-info":[{"award-number":["R01 EB036124"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Hyperbaric oxygen (HBO) therapy increases blood oxygen levels by exposing patients to 100% oxygen under elevated pressure and is used clinically for conditions such as decompression sickness, carbon monoxide poisoning, chronic wounds, and impaired tissue healing. However, real\u2010time precise and quantitative measurement of tissue oxygen tension (pO\n                      <jats:sub>2<\/jats:sub>\n                      ) under hyperbaric conditions remains technically very challenging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We developed a specialized small\u2010animal hyperbaric chamber compatible with in vivo electron paramagnetic resonance (EPR) oximetry using customized OxyTrack oxygen detectors. Up to two detectors were implanted simultaneously to measure pO\n                      <jats:sub>2<\/jats:sub>\n                      in skeletal muscle and tumor tissue in mice. Animals were exposed to air (21% O\n                      <jats:sub>2<\/jats:sub>\n                      ) and 100% O\n                      <jats:sub>2<\/jats:sub>\n                      at both normobaric pressure and 2 atmospheres absolute (ATA) in a stepwise protocol.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The chamber operated safely and stably up to 2 ATA, enabling continuous real\u2010time pO\n                      <jats:sub>2<\/jats:sub>\n                      monitoring without adverse events and issues with the hardware for up to 90\u2009min. In B16\u2010F10 melanoma, tumor pO\n                      <jats:sub>2<\/jats:sub>\n                      increased from \u223c9\u2009mmHg at baseline to \u223c26\u2009mmHg at 100% O\n                      <jats:sub>2<\/jats:sub>\n                      (1 ATA) and \u223c50\u2009mmHg at 2 ATA, with partial retention after decompression. In contrast, SCC7 tumors showed minimal responsiveness (\u223c9\u201310\u2009mmHg), whereas skeletal muscle demonstrated marked pressure\u2010dependent increases (up to \u223c50\u2009mmHg).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The small\u2010animal HBO chamber enables real\u2010time, tissue\u2010specific assessment of oxygen dynamics under clinically relevant hyperbaric conditions. The approach could facilitate optimization of HBO protocols and support translational investigation of oxygen\u2010modulated therapies, including radiation and drug responses in solid tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70444","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:29:37Z","timestamp":1782102577000},"page":"2019-2028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010Time Monitoring of Tissue Oxygenation During Hyperbaric Oxygen Exposure Using In Vivo\n                    <scp>EPR<\/scp>\n                    Oximetry"],"prefix":"10.1002","volume":"96","author":[{"given":"Maciej M.","family":"Kmiec","sequence":"first","affiliation":[{"name":"Department of Radiology Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V.","family":"Petryakov","sequence":"additional","affiliation":[{"name":"Department of Radiology Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Kheirollah","sequence":"additional","affiliation":[{"name":"Department of Surgery Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conner S.","family":"Ubert","sequence":"additional","affiliation":[{"name":"Department of Radiology Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Department of Radiology Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Periannan","family":"Kuppusamy","sequence":"additional","affiliation":[{"name":"Department of Radiology Geisel School of Medicine, Dartmouth College  Hanover New Hampshire USA"},{"name":"Department of Radiation Oncology and Applied Sciences Geisel School of Medicine and Dartmouth\u2010Hitchcock Hospital  Lebanon New Hampshire 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