{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:01:35Z","timestamp":1785445295629,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41 EB027061"],"award-info":[{"award-number":["P41 EB027061"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01 EB030000"],"award-info":[{"award-number":["R01 EB030000"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Magnetic resonance spectroscopy techniques are widely used to non\u2010invasively study brain metabolism. Despite advances in magnetic resonance spectroscopic imaging (MRSI), there is a notable absence of research on comparing fast non\u2010Cartesian MRSI with single\u2010voxel spectroscopy (SVS), limiting our understanding of its performance and applicability. In this study, we compared the spectral quality and metabolite concentrations obtained using short\u2010T\n                      <jats:sub>E<\/jats:sub>\n                      2D spiral MRSI and SVS in the same region in the human brain at 3T.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five healthy subjects were scanned at 3T. 2D spiral MRSI data were acquired in a transverse slice through the posterior cingulate cortex (PCC), while the SVS volume was placed within the PCC region. Both techniques employed the standardized semi\u2010LASER sequence for localization. All data were processed in Matlab and fitted with LCModel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Visual inspection suggested comparable overall spectral quality between the two acquisitions. Quantitatively, however, the PCC voxel measured with MRSI exhibited lower signal\u2010to\u2010noise ratio (SNR) compared to SVS at identical scan times, when the SVS voxel matched the effective MRSI voxel. Consistent with lower SNR, metabolite quantification showed higher Cramer\u2010Rao lower bounds with MRSI. In addition, concentrations of glutamate and glutamate plus glutamine were lower with MRSI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrate that the quality of semi\u2010LASER localized short\u2010TE spiral MRSI spectra is very comparable to that of semi\u2010LASER localized SVS spectra. Small metabolic\u2010specific concentration differences may be due to different WM\/GM tissue weighting within the voxel (slice selection profile in SVS vs. point\u2010spread function in MRSI) and different SNR between the two techniques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70463","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:31:37Z","timestamp":1780720297000},"page":"1524-1533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short Echo\u2010Time Spiral\n                    <scp>MRSI<\/scp>\n                    Versus Single\u2010Voxel Spectroscopy in the Human Brain at 3 Tesla With Semi\u2010\n                    <scp>LASER<\/scp>\n                    Localization"],"prefix":"10.1002","volume":"96","author":[{"given":"Young Woo","family":"Park","sequence":"first","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis Minnesota USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc  Bethesda Maryland USA"},{"name":"Department of Radiology Uniformed Services University of the Health Sciences  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-5877","authenticated-orcid":false,"given":"Isaac M.","family":"Adanyeguh","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Gilles","family":"Henry","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4266-4780","authenticated-orcid":false,"given":"Dinesh K.","family":"Deelchand","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27742"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4236"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1053"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3898"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4309"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4314"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4046"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.70185"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470034590.emrstm1439"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22708"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099\u20101492(199712)10:8<423::AID\u2010NBM488>3.0.CO;2\u2010X"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4218"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4459"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1522\u20102594(200002)43:2<319::aid\u2010mrm22>3.0.co;2\u20101"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29164"},{"key":"e_1_2_11_17_1","unstructured":"D. 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