{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:58:58Z","timestamp":1790654338658,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R44CA302113\u201001A1"],"award-info":[{"award-number":["R44CA302113\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      The partial pressure of oxygen (pO\n                      <jats:sub>2<\/jats:sub>\n                      ) in tissue is a tightly regulated physiological quantity. Hypoxia is a hallmark of many diseases, and changes in tissue pO\n                      <jats:sub>2<\/jats:sub>\n                      underline critical developmental, metabolic, and physiological processes. Electron paramagnetic resonance oxygen imaging (EPROI) has emerged as the most precise technique to image pO\n                      <jats:sub>2<\/jats:sub>\n                      in vitro and in vivo. EPROI uses linear relationship between the relaxation rates (R\n                      <jats:sub>1<\/jats:sub>\n                      or R\n                      <jats:sub>2<\/jats:sub>\n                      ) of the spin probe OXO71 and pO\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The current gold standard for EPROI is inversion recovery electron spin echo (IRESE) sequence with radial\n                      <jats:italic>k<\/jats:italic>\n                      \u2010space acquisition scheme, which is fast, provides high pO\n                      <jats:sub>2<\/jats:sub>\n                      resolution using T\n                      <jats:sub>1<\/jats:sub>\n                      imaging, but suffers from low spatial resolution, especially at higher oxygen concentrations. The other method, single\u2010point imaging (SPI), which uses Cartesian\n                      <jats:italic>k<\/jats:italic>\n                      \u2010space acquisition scheme and free\u2010induction decay (FID) readout, provides higher spatial resolution but has lower signal\u2010to\u2010noise ratio (SNR) and lower pO\n                      <jats:sub>2<\/jats:sub>\n                      accuracy, especially for\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      * imaging. In this work, we introduce advanced inversion\u2010recovery single\u2010point imaging (AIR\u2010SPI), which combines inversion\u2010recovery SPI (IR\u2010SPI) with multi\u2010point FID averaging in the spatial domain. We evaluate the performance of AIR\u2010SPI in phantoms and in vivo imaging of a fibrosarcoma (FSA) tumor in a mouse leg.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We demonstrate 2\u20138\u2010fold SNR improvement and higher spatial resolution for AIR\u2010SPI compared to IR\u2010SPI and IRESE, especially for high oxygen concentrations. We also demonstrate higher pO\n                      <jats:sub>2<\/jats:sub>\n                      precision for AIR\u2010SPI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AIR\u2010SPI offers improvements in image SNR, spatial, and oxygen resolution over all existing EPR oxygen imaging methods, without increasing imaging time. Importantly, it uses smaller RF power than echo\u2010based methods, which is crucial for scaling EPROI to human applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.70538","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:58:31Z","timestamp":1787752711000},"page":"3021-3032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advanced Inversion Recovery Single Point Imaging for High Spatial Resolution and Quantitative Oxygen Imaging"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-7029","authenticated-orcid":false,"given":"Boris","family":"Epel","sequence":"first","affiliation":[{"name":"Oxygen Measurement Core O2M Technologies, LLC  Chicago Illinois USA"},{"name":"Department of Radiation and Cellular Oncology The University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3933-3271","authenticated-orcid":false,"given":"Irene","family":"Canavesi","sequence":"additional","affiliation":[{"name":"Oxygen Measurement Core O2M Technologies, LLC  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2264-0247","authenticated-orcid":false,"given":"Mrignayani","family":"Kotecha","sequence":"additional","affiliation":[{"name":"Oxygen Measurement Core O2M Technologies, LLC  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Guyton and Hall Textbook of Medical Physiology","author":"Hall J. E.","year":"2015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2017.04.017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-024-01908-y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-42099-w"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA08633A"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.70214"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3555297"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-024-01963-5"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29994"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1269689"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-024-01925-x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2025.111329"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44303-024-00013-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00215.2025"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-0928"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-023-01852-3"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24926"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29811"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27008"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.30473"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmra.1996.0225"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10199"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20849"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmr.b.20119"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20872"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21194"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1994.1052"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24508"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2016.10.029"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2012.03.022"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2015.02.012"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27182"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41233"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.10.041"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24886"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25282"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrm.70538","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.70538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:43:16Z","timestamp":1790653396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.70538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1002\/mrm.70538"],"URL":"https:\/\/doi.org\/10.1002\/mrm.70538","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"assertion":[{"value":"2026-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}